Separation of absorption and scattering profiles in spectroscopic optical coherence tomography using a least-squares algorithm

Published

Journal Article

In spectroscopic optical coherence tomography, it is important and useful to separately estimate the absorption and the scattering properties of tissue. In this paper, we propose a least-squares fitting algorithm to separate absorption and scattering profiles when near-infrared absorbing dyes are used. The algorithm utilizes the broadband Ti:sapphire laser spectrum together with joint time-frequency analysis. Noise contribution to the final estimation was analyzed using simulation. The validity of our algorithm was demonstrated using both single-layer and multi-layer tissue phantoms. © 2004 Optical Society of America.

Full Text

Cited Authors

  • Xu, C; Marks, DL; Do, MN; Boppart, SA

Published Date

  • January 1, 2004

Published In

Volume / Issue

  • 12 / 20

Start / End Page

  • 4790 - 4803

International Standard Serial Number (ISSN)

  • 1094-4087

Digital Object Identifier (DOI)

  • 10.1364/OPEX.12.004790

Citation Source

  • Scopus