Functional optical coherence tomography for detecting neural activity through scattering changes


Journal Article

We have demonstrated functional optical coherence tomography (fOCT) for neural imaging by detecting scattering changes during the propagation of action potentials through neural tissue. OCT images of nerve fibers from the abdominal ganglion of the sea slug Aplysia californica were taken before, during, and after electrical stimulation. Images acquired during stimulation showed localized reversible increases in scattering compared with those acquired before stimulation. Motion-mode OCT images of nerve fibers showed transient scattering changes from spontaneous action potentials. These results demonstrate that OCT is sensitive to the optical changes in electrically active nerve fibers. © 2003 Optical Society of America.

Full Text

Duke Authors

Cited Authors

  • Lazebnik, M; Marks, DL; Potgieter, K; Gillette, R; Boppart, SA

Published Date

  • July 15, 2003

Published In

Volume / Issue

  • 28 / 14

Start / End Page

  • 1218 - 1220

International Standard Serial Number (ISSN)

  • 0146-9592

Digital Object Identifier (DOI)

  • 10.1364/OL.28.001218

Citation Source

  • Scopus