Pregabalin augmentation of antidepressants in patients with accident-related posttraumatic stress disorder: an open label pilot study.
Published
Journal Article
This study evaluated the efficacy of pregabalin augmentation of antidepressant treatment in patients with posttraumatic stress disorder (PTSD). Nine patients meeting Diagnostic and Statistical Manual, fourth edition criteria for PTSD who were on stable doses of antidepressants were treated open label with flexibly dosed pregabalin for 6 weeks. All patients were assessed with the Short PTSD Rating Interview, Montgomery-Asberg Depression Rating Scale, Patient Global Impression-severity, Visual Analog Scale-pain, and Sheehan Disability Scale at baseline and weeks 2, 4, and 6. Significant reductions were observed in all effectiveness measures from week 4 to the end of the study. In particular, the numerical improvement of the Visual Analog Scale-pain score was most robust (-53.4%, P=0.007). Pregabalin augmentation was effective and well tolerated during the study. Our findings warrant adequately powered, placebo-controlled clinical trials to confirm the usefulness of pregabalin augmentation of antidepressants in patients with PTSD.
Full Text
Duke Authors
Cited Authors
- Pae, C-U; Marks, DM; Han, C; Masand, PS; Patkar, AA
Published Date
- January 2009
Published In
Volume / Issue
- 24 / 1
Start / End Page
- 29 - 33
PubMed ID
- 19060720
Pubmed Central ID
- 19060720
International Standard Serial Number (ISSN)
- 0268-1315
Digital Object Identifier (DOI)
- 10.1097/YIC.0b013e32831feea9
Language
- eng
Conference Location
- England