Skip to main content

Desvenlafaxine, a serotonin-norepinephrine uptake inhibitor for major depressive disorder, neuropathic pain and the vasomotor symptoms associated with menopause.

Publication ,  Journal Article
Pae, C-U; Park, M-H; Marks, DM; Han, C; Patkar, AA; Masand, PS
Published in: Curr Opin Investig Drugs
January 2009

Desvenlafaxine, a serotonin-norepinephrine reuptake inhibitor (SNRI) developed by Wyeth, is a novel salt form of the isolated major active metabolite of the antidepressant venlafaxine. Desvenlafaxine was developed as a slow-release tablet formulation and rapidly penetrates the brain upon administration supporting its direct effects on neuronal systems of the brain. Unlike various other antidepressants including venlafaxine, desvenlafaxine is not metabolized by cytochrome p450 (CYP) enzyme pathways and is associated with minimal inhibition of CYP enzymes. This feature results in a comparatively low risk of drug-drug interaction and consistent intra-individual and inter-individual pharmacokinetic profiles. Desvenlafaxine has been recently approved by the US FDA for the treatment of major depressive disorder (MDD) based on a series of randomized, double-blind, placebo-controlled clinical trials indicating efficacy and safety for patients with MDD. Studies have also supported the potential utility of desvenlafaxine in the treatment of vasomotor symptoms of menopause, anxiety symptoms and painful physical symptoms. However, concerns including mixed efficacy and adverse events need to be further explored in future studies.

Duke Scholars

Published In

Curr Opin Investig Drugs

EISSN

2040-3429

Publication Date

January 2009

Volume

10

Issue

1

Start / End Page

75 / 90

Location

England

Related Subject Headings

  • Vasomotor System
  • Structure-Activity Relationship
  • Selective Serotonin Reuptake Inhibitors
  • Pharmacology & Pharmacy
  • Norepinephrine
  • Neuralgia
  • Molecular Structure
  • Menopause
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Pae, C.-U., Park, M.-H., Marks, D. M., Han, C., Patkar, A. A., & Masand, P. S. (2009). Desvenlafaxine, a serotonin-norepinephrine uptake inhibitor for major depressive disorder, neuropathic pain and the vasomotor symptoms associated with menopause. Curr Opin Investig Drugs, 10(1), 75–90.
Pae, Chi-Un, Min-Hyeon Park, David M. Marks, Changsu Han, Ashwin A. Patkar, and Prakash S. Masand. “Desvenlafaxine, a serotonin-norepinephrine uptake inhibitor for major depressive disorder, neuropathic pain and the vasomotor symptoms associated with menopause.Curr Opin Investig Drugs 10, no. 1 (January 2009): 75–90.
Pae C-U, Park M-H, Marks DM, Han C, Patkar AA, Masand PS. Desvenlafaxine, a serotonin-norepinephrine uptake inhibitor for major depressive disorder, neuropathic pain and the vasomotor symptoms associated with menopause. Curr Opin Investig Drugs. 2009 Jan;10(1):75–90.
Pae C-U, Park M-H, Marks DM, Han C, Patkar AA, Masand PS. Desvenlafaxine, a serotonin-norepinephrine uptake inhibitor for major depressive disorder, neuropathic pain and the vasomotor symptoms associated with menopause. Curr Opin Investig Drugs. 2009 Jan;10(1):75–90.

Published In

Curr Opin Investig Drugs

EISSN

2040-3429

Publication Date

January 2009

Volume

10

Issue

1

Start / End Page

75 / 90

Location

England

Related Subject Headings

  • Vasomotor System
  • Structure-Activity Relationship
  • Selective Serotonin Reuptake Inhibitors
  • Pharmacology & Pharmacy
  • Norepinephrine
  • Neuralgia
  • Molecular Structure
  • Menopause
  • Humans
  • Female