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Molecular markers in ductal carcinoma in situ of the breast.

Publication ,  Journal Article
Porter, D; Lahti-Domenici, J; Keshaviah, A; Bae, YK; Argani, P; Marks, J; Richardson, A; Cooper, A; Strausberg, R; Riggins, GJ; Schnitt, S ...
Published in: Mol Cancer Res
March 2003

Gene expression patterns in ductal carcinoma in situ (DCIS), and in invasive, and metastatic breast tumors were determined using serial analysis of gene expression (SAGE). We used mRNA in situ hybridization to examine gene expression at the cellular level and immunohistochemistry on tissue microarrays to determine association between gene expression patterns and histopathologic characteristics of the tumors. We found that that the most dramatic transcriptome change occurs at the normal to DCIS transition, while there is no clear universal "in situ" or "invasive" tumor molecular signature. From the 16,430 transcripts analyzed, we identified only 5 and 11 that were preferentially up-regulated in DCIS and invasive tumors, respectively. The majority of invasive cancer specific SAGE tags correspond to novel genes. The genes we identified may define biologically and clinically meaningful subgroups of DCIS with a high risk of progression to invasive disease.

Duke Scholars

Published In

Mol Cancer Res

ISSN

1541-7786

Publication Date

March 2003

Volume

1

Issue

5

Start / End Page

362 / 375

Location

United States

Related Subject Headings

  • Up-Regulation
  • Oncology & Carcinogenesis
  • Oligonucleotide Array Sequence Analysis
  • Immunohistochemistry
  • Humans
  • Genetic Markers
  • Gene Library
  • Gene Expression Regulation, Neoplastic
  • Female
  • Down-Regulation
 

Citation

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MLA
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Porter, D., Lahti-Domenici, J., Keshaviah, A., Bae, Y. K., Argani, P., Marks, J., … Polyak, K. (2003). Molecular markers in ductal carcinoma in situ of the breast. Mol Cancer Res, 1(5), 362–375.
Porter, Dale, Jaana Lahti-Domenici, Aparna Keshaviah, Young Kyung Bae, Pedram Argani, Jeffrey Marks, Andrea Richardson, et al. “Molecular markers in ductal carcinoma in situ of the breast.Mol Cancer Res 1, no. 5 (March 2003): 362–75.
Porter D, Lahti-Domenici J, Keshaviah A, Bae YK, Argani P, Marks J, et al. Molecular markers in ductal carcinoma in situ of the breast. Mol Cancer Res. 2003 Mar;1(5):362–75.
Porter, Dale, et al. “Molecular markers in ductal carcinoma in situ of the breast.Mol Cancer Res, vol. 1, no. 5, Mar. 2003, pp. 362–75.
Porter D, Lahti-Domenici J, Keshaviah A, Bae YK, Argani P, Marks J, Richardson A, Cooper A, Strausberg R, Riggins GJ, Schnitt S, Gabrielson E, Gelman R, Polyak K. Molecular markers in ductal carcinoma in situ of the breast. Mol Cancer Res. 2003 Mar;1(5):362–375.

Published In

Mol Cancer Res

ISSN

1541-7786

Publication Date

March 2003

Volume

1

Issue

5

Start / End Page

362 / 375

Location

United States

Related Subject Headings

  • Up-Regulation
  • Oncology & Carcinogenesis
  • Oligonucleotide Array Sequence Analysis
  • Immunohistochemistry
  • Humans
  • Genetic Markers
  • Gene Library
  • Gene Expression Regulation, Neoplastic
  • Female
  • Down-Regulation