Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia.

Published

Journal Article

Although five-year survival rates for childhood acute lymphoblastic leukemia (ALL) are now over 80% in most industrialized countries, not all children have benefited equally from this progress. Ethnic differences in survival after childhood ALL have been reported in many clinical studies, with poorer survival observed among African Americans or those with Hispanic ethnicity when compared with European Americans or Asians. The causes of ethnic differences remain uncertain, although both genetic and non-genetic factors are likely important. Interrogating genome-wide germline SNP genotypes in an unselected large cohort of children with ALL, we observed that the component of genomic variation that co-segregated with Native American ancestry was associated with risk of relapse (P = 0.0029) even after adjusting for known prognostic factors (P = 0.017). Ancestry-related differences in relapse risk were abrogated by the addition of a single extra phase of chemotherapy, indicating that modifications to therapy can mitigate the ancestry-related risk of relapse.

Full Text

Duke Authors

Cited Authors

  • Yang, JJ; Cheng, C; Devidas, M; Cao, X; Fan, Y; Campana, D; Yang, W; Neale, G; Cox, NJ; Scheet, P; Borowitz, MJ; Winick, NJ; Martin, PL; Willman, CL; Bowman, WP; Camitta, BM; Carroll, A; Reaman, GH; Carroll, WL; Loh, M; Hunger, SP; Pui, C-H; Evans, WE; Relling, MV

Published Date

  • March 2011

Published In

Volume / Issue

  • 43 / 3

Start / End Page

  • 237 - 241

PubMed ID

  • 21297632

Pubmed Central ID

  • 21297632

Electronic International Standard Serial Number (EISSN)

  • 1546-1718

International Standard Serial Number (ISSN)

  • 1061-4036

Digital Object Identifier (DOI)

  • 10.1038/ng.763

Language

  • eng