Neuroactive steroids and suicidality in posttraumatic stress disorder.

Journal Article (Journal Article)

OBJECTIVE: Recent studies suggest that neuroactive steroids may be altered in posttraumatic stress disorder (PTSD). Since high rates of suicidality accompany PTSD, the authors investigated neuroactive steroid levels and correlations to suicide attempts in veterans with this disorder. METHOD: Male veterans with PTSD enrolled in a larger study during inpatient hospitalization (N=130) were assessed for suicidal ideation or suicide attempt in the last 6 months. Serum levels of dehydroepiandrosterone (DHEA), androstenedione, testosterone, and estradiol were determined. The authors investigated associations between neuroactive steroids and suicidality. RESULTS: High rates of suicidality were observed. Close to 70% of these patients had suicidal thoughts, and 25% had attempted suicide in the last 6 months. Patients who had attempted suicide demonstrated significantly higher median DHEA levels than those who had not attempted suicide (15.6 versus 8.3 ng/ml), an association that persisted after adjustment for age. CONCLUSIONS: These findings suggest that higher DHEA levels may be linked to suicidality in veterans with PTSD and may be associated with the risk of self-harm.

Full Text

Duke Authors

Cited Authors

  • Butterfield, MI; Stechuchak, KM; Connor, KM; Davidson, JRT; Wang, C; MacKuen, CL; Pearlstein, AM; Marx, CE

Published Date

  • February 2005

Published In

Volume / Issue

  • 162 / 2

Start / End Page

  • 380 - 382

PubMed ID

  • 15677605

International Standard Serial Number (ISSN)

  • 0002-953X

Digital Object Identifier (DOI)

  • 10.1176/appi.ajp.162.2.380


  • eng

Conference Location

  • United States