Predictive value of single-fiber electromyography in the extensor digitorum communis muscle of patients with ocular myasthenia gravis: a retrospective study.


Journal Article

PURPOSE: To determine if the jitter in the extensor digitorum communis (EDC) muscle in patients with purely ocular myasthenia gravis (OMG) predicts the subsequent development of generalized myasthenic weakness-Methods: Included in this retrospective study were patients who initially had purely ocular manifestations and had been followed for at least 2 years after onset of myasthenic symptoms. The group consisted of 50 patients with purely ocular weakness, 26 of whom later generalized. All underwent single-fiber electromyography (SFEMG) studies in the EDC muscle at the initial examination RESULTS: : Statistical analysis did not demonstrate that the amount of jitter in the EDC muscle predicted the development of generalized myasthenia gravis (GMG). Also, there was no threshold jitter value that predicted generalized weakness. CONCLUSIONS: : SFEMG measurement of jitter in the EDC muscle demonstrates abnormal neuromuscular transmission in many patients with OMG but is not useful in predicting generalization in these patients.

Full Text

Duke Authors

Cited Authors

  • Rostedt, A; Saders, LL; Edards, LJ; Massey, JM; Sanders, DB; Stålberg, EV

Published Date

  • September 2000

Published In

Volume / Issue

  • 2 / 1

Start / End Page

  • 6 - 9

PubMed ID

  • 19078595

Pubmed Central ID

  • 19078595

Electronic International Standard Serial Number (EISSN)

  • 1537-1611

Digital Object Identifier (DOI)

  • 10.1097/00131402-200009000-00003


  • eng

Conference Location

  • United States