Network calisthenics: control of E2F dynamics in cell cycle entry.

Journal Article (Journal Article;Review)

Stimulation of quiescent mammalian cells with mitogens induces an abrupt increase in E2F1-3 expression just prior to the onset of DNA synthesis, followed by a rapid decline as replication ceases. This temporal adaptation in E2F facilitates a transient pattern of gene expression that reflects the ordered nature of DNA replication. The challenge to understand how E2F dynamics coordinate molecular events required for high-fidelity DNA replication has great biological implications. Indeed, precocious, prolonged, elevated or reduced accumulation of E2F can generate replication stress that culminates in either arrest or death. Accordingly, temporal characteristics of E2F are regulated by several network modules that include feedforward and autoregulatory loops. In this review, we discuss how these network modules contribute to "shaping" E2F dynamics in the context of mammalian cell cycle entry.

Full Text

Duke Authors

Cited Authors

  • Wong, JV; Dong, P; Nevins, JR; Mathey-Prevot, B; You, L

Published Date

  • September 15, 2011

Published In

Volume / Issue

  • 10 / 18

Start / End Page

  • 3086 - 3094

PubMed ID

  • 21900750

Pubmed Central ID

  • PMC3218619

Electronic International Standard Serial Number (EISSN)

  • 1551-4005

Digital Object Identifier (DOI)

  • 10.4161/cc.10.18.17350


  • eng

Conference Location

  • United States