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Network calisthenics: control of E2F dynamics in cell cycle entry.

Publication ,  Journal Article
Wong, JV; Dong, P; Nevins, JR; Mathey-Prevot, B; You, L
Published in: Cell Cycle
September 15, 2011

Stimulation of quiescent mammalian cells with mitogens induces an abrupt increase in E2F1-3 expression just prior to the onset of DNA synthesis, followed by a rapid decline as replication ceases. This temporal adaptation in E2F facilitates a transient pattern of gene expression that reflects the ordered nature of DNA replication. The challenge to understand how E2F dynamics coordinate molecular events required for high-fidelity DNA replication has great biological implications. Indeed, precocious, prolonged, elevated or reduced accumulation of E2F can generate replication stress that culminates in either arrest or death. Accordingly, temporal characteristics of E2F are regulated by several network modules that include feedforward and autoregulatory loops. In this review, we discuss how these network modules contribute to "shaping" E2F dynamics in the context of mammalian cell cycle entry.

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Published In

Cell Cycle

DOI

EISSN

1551-4005

Publication Date

September 15, 2011

Volume

10

Issue

18

Start / End Page

3086 / 3094

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • Signal Transduction
  • Retinoblastoma-Like Protein p107
  • Replication Origin
  • Proto-Oncogene Proteins c-myc
  • Promoter Regions, Genetic
  • Phosphorylation
  • Neoplasms
  • MicroRNAs
  • Mammals
 

Citation

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Wong, J. V., Dong, P., Nevins, J. R., Mathey-Prevot, B., & You, L. (2011). Network calisthenics: control of E2F dynamics in cell cycle entry. Cell Cycle, 10(18), 3086–3094. https://doi.org/10.4161/cc.10.18.17350
Wong, Jeffrey V., Peng Dong, Joseph R. Nevins, Bernard Mathey-Prevot, and Lingchong You. “Network calisthenics: control of E2F dynamics in cell cycle entry.Cell Cycle 10, no. 18 (September 15, 2011): 3086–94. https://doi.org/10.4161/cc.10.18.17350.
Wong JV, Dong P, Nevins JR, Mathey-Prevot B, You L. Network calisthenics: control of E2F dynamics in cell cycle entry. Cell Cycle. 2011 Sep 15;10(18):3086–94.
Wong, Jeffrey V., et al. “Network calisthenics: control of E2F dynamics in cell cycle entry.Cell Cycle, vol. 10, no. 18, Sept. 2011, pp. 3086–94. Pubmed, doi:10.4161/cc.10.18.17350.
Wong JV, Dong P, Nevins JR, Mathey-Prevot B, You L. Network calisthenics: control of E2F dynamics in cell cycle entry. Cell Cycle. 2011 Sep 15;10(18):3086–3094.

Published In

Cell Cycle

DOI

EISSN

1551-4005

Publication Date

September 15, 2011

Volume

10

Issue

18

Start / End Page

3086 / 3094

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • Signal Transduction
  • Retinoblastoma-Like Protein p107
  • Replication Origin
  • Proto-Oncogene Proteins c-myc
  • Promoter Regions, Genetic
  • Phosphorylation
  • Neoplasms
  • MicroRNAs
  • Mammals