Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens.

Journal Article (Journal Article;Review)

RNA interference (RNAi) and small-molecule approaches are synergistic on multiple levels, from technology and high-throughput screen development to target identification and functional studies. Here, we describe the RNAi screening platform that we have established and made available to the community through the Drosophila RNAi Screening Center at Harvard Medical School. We then illustrate how the combination of RNAi and small-molecule HTS can lead to effective identification of targets in drug discovery.

Full Text

Duke Authors

Cited Authors

  • Perrimon, N; Friedman, A; Mathey-Prevot, B; Eggert, US

Published Date

  • January 1, 2007

Published In

Volume / Issue

  • 12 / 1-2

Start / End Page

  • 28 - 33

PubMed ID

  • 17198970

International Standard Serial Number (ISSN)

  • 1359-6446

Digital Object Identifier (DOI)

  • 10.1016/j.drudis.2006.10.006


  • eng

Conference Location

  • England