Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens.
Publication
, Journal Article
Perrimon, N; Friedman, A; Mathey-Prevot, B; Eggert, US
Published in: Drug Discov Today
January 2007
RNA interference (RNAi) and small-molecule approaches are synergistic on multiple levels, from technology and high-throughput screen development to target identification and functional studies. Here, we describe the RNAi screening platform that we have established and made available to the community through the Drosophila RNAi Screening Center at Harvard Medical School. We then illustrate how the combination of RNAi and small-molecule HTS can lead to effective identification of targets in drug discovery.
Duke Scholars
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Published In
Drug Discov Today
DOI
ISSN
1359-6446
Publication Date
January 2007
Volume
12
Issue
1-2
Start / End Page
28 / 33
Location
England
Related Subject Headings
- RNA, Small Interfering
- RNA Interference
- Medicinal & Biomolecular Chemistry
- Drug Evaluation, Preclinical
- Drug Design
- Drug Delivery Systems
- Drosophila
- Animals
- 3214 Pharmacology and pharmaceutical sciences
- 1115 Pharmacology and Pharmaceutical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Perrimon, N., Friedman, A., Mathey-Prevot, B., & Eggert, U. S. (2007). Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens. Drug Discov Today, 12(1–2), 28–33. https://doi.org/10.1016/j.drudis.2006.10.006
Perrimon, Norbert, Adam Friedman, Bernard Mathey-Prevot, and Ulrike S. Eggert. “Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens.” Drug Discov Today 12, no. 1–2 (January 2007): 28–33. https://doi.org/10.1016/j.drudis.2006.10.006.
Perrimon N, Friedman A, Mathey-Prevot B, Eggert US. Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens. Drug Discov Today. 2007 Jan;12(1–2):28–33.
Perrimon, Norbert, et al. “Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens.” Drug Discov Today, vol. 12, no. 1–2, Jan. 2007, pp. 28–33. Pubmed, doi:10.1016/j.drudis.2006.10.006.
Perrimon N, Friedman A, Mathey-Prevot B, Eggert US. Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens. Drug Discov Today. 2007 Jan;12(1–2):28–33.
Published In
Drug Discov Today
DOI
ISSN
1359-6446
Publication Date
January 2007
Volume
12
Issue
1-2
Start / End Page
28 / 33
Location
England
Related Subject Headings
- RNA, Small Interfering
- RNA Interference
- Medicinal & Biomolecular Chemistry
- Drug Evaluation, Preclinical
- Drug Design
- Drug Delivery Systems
- Drosophila
- Animals
- 3214 Pharmacology and pharmaceutical sciences
- 1115 Pharmacology and Pharmaceutical Sciences