Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury.
Journal Article (Journal Article)
To characterize the features of JAK/STAT signaling in Drosophila immune response, we have identified totA as a gene that is regulated by the JAK/STAT pathway in response to septic injury. We show that septic injury triggers the hemocyte-specific expression of upd3, a gene encoding a novel Upd-like cytokine that is necessary for the JAK/STAT-dependent activation of totA in the Drosophila counterpart of the mammalian liver, the fat body. In addition, we demonstrate that totA activation also requires the NF-KB-like Relish pathway, indicating that fat body cells integrate the activity of NF-KB and JAK/STAT signaling pathways upon immune response. This study reveals that, in addition to the pattern recognition receptor-mediated NF-KB-dependent immune response, Drosophila undergoes a complex systemic response that is mediated by the production of cytokines in blood cells, a process that is similar to the acute phase response in mammals.
Full Text
Duke Authors
Cited Authors
- Agaisse, H; Petersen, UM; Boutros, M; Mathey-Prevot, B; Perrimon, N
Published Date
- September 2003
Published In
Volume / Issue
- 5 / 3
Start / End Page
- 441 - 450
PubMed ID
- 12967563
Pubmed Central ID
- 12967563
International Standard Serial Number (ISSN)
- 1534-5807
Digital Object Identifier (DOI)
- 10.1016/s1534-5807(03)00244-2
Language
- eng
Conference Location
- United States