Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury.

Published

Journal Article

To characterize the features of JAK/STAT signaling in Drosophila immune response, we have identified totA as a gene that is regulated by the JAK/STAT pathway in response to septic injury. We show that septic injury triggers the hemocyte-specific expression of upd3, a gene encoding a novel Upd-like cytokine that is necessary for the JAK/STAT-dependent activation of totA in the Drosophila counterpart of the mammalian liver, the fat body. In addition, we demonstrate that totA activation also requires the NF-KB-like Relish pathway, indicating that fat body cells integrate the activity of NF-KB and JAK/STAT signaling pathways upon immune response. This study reveals that, in addition to the pattern recognition receptor-mediated NF-KB-dependent immune response, Drosophila undergoes a complex systemic response that is mediated by the production of cytokines in blood cells, a process that is similar to the acute phase response in mammals.

Full Text

Duke Authors

Cited Authors

  • Agaisse, H; Petersen, UM; Boutros, M; Mathey-Prevot, B; Perrimon, N

Published Date

  • September 2003

Published In

Volume / Issue

  • 5 / 3

Start / End Page

  • 441 - 450

PubMed ID

  • 12967563

Pubmed Central ID

  • 12967563

Electronic International Standard Serial Number (EISSN)

  • 1878-1551

International Standard Serial Number (ISSN)

  • 1534-5807

Digital Object Identifier (DOI)

  • 10.1016/s1534-5807(03)00244-2

Language

  • eng