A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice.

Journal Article

Transgenic mice carrying an immunoglobulin enhancer-driven c-myc oncogene develop rapid-onset pre-B cell lymphomas. The incidence of these malignancies is greatly reduced when an additional transgene encoding the membrane-bound form (but not the secreted form) of human Ig mu is bred into the susceptible strain. This suppressive effect correlates with a subtle alteration in B-cell development induced by the immunoglobulin transgene.

Full Text

Duke Authors

Cited Authors

  • Nussenzweig, MC; Schmidt, EV; Shaw, AC; Sinn, E; Campos-Torres, J; Mathey-Prevot, B; Pattengale, PK; Leder, P

Published Date

  • December 1, 1988

Published In

Volume / Issue

  • 336 / 6198

Start / End Page

  • 446 - 450

PubMed ID

  • 3143076

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/336446a0

Language

  • eng

Conference Location

  • England