A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice.
Journal Article (Journal Article)
Transgenic mice carrying an immunoglobulin enhancer-driven c-myc oncogene develop rapid-onset pre-B cell lymphomas. The incidence of these malignancies is greatly reduced when an additional transgene encoding the membrane-bound form (but not the secreted form) of human Ig mu is bred into the susceptible strain. This suppressive effect correlates with a subtle alteration in B-cell development induced by the immunoglobulin transgene.
Full Text
Duke Authors
Cited Authors
- Nussenzweig, MC; Schmidt, EV; Shaw, AC; Sinn, E; Campos-Torres, J; Mathey-Prevot, B; Pattengale, PK; Leder, P
Published Date
- December 1, 1988
Published In
Volume / Issue
- 336 / 6198
Start / End Page
- 446 - 450
PubMed ID
- 3143076
International Standard Serial Number (ISSN)
- 0028-0836
Digital Object Identifier (DOI)
- 10.1038/336446a0
Language
- eng
Conference Location
- England