RAMP like proteins : RTP and REEP family of proteins.


Journal Article (Review)

Mammalian odorant receptors (ORs) are typically retained in the endoplasmic reticulum (ER) when expressed in heterologous cells. The RTP (Receptor-Transporting Protein) and REEP (Receptor Expression Enhancing Protein) family of proteins were first identified as partners for ORs, promoting cell-surface expression and leading to functional responses in heterologous cell systems. Like RAMPs, the RTP and REEP proteins appear to partner with GPCRs to promote cell-surface expression. Unlike RAMPs, they do not appear to alter the pharmacology of the partner receptor.

Full Text

Duke Authors

Cited Authors

  • Mainland, J; Matsunami, H

Published Date

  • 2012

Published In

Volume / Issue

  • 744 /

Start / End Page

  • 75 - 86

PubMed ID

  • 22434109

Pubmed Central ID

  • 22434109

International Standard Serial Number (ISSN)

  • 0065-2598

Digital Object Identifier (DOI)

  • 10.1007/978-1-4614-2364-5_7


  • eng

Conference Location

  • United States