SR1, a mouse odorant receptor with an unusually broad response profile.

Journal Article (Journal Article)

The current consensus model in mammalian olfaction is that the detection of millions of odorants requires a large number of odorant receptors (ORs) and that each OR interacts selectively with a small subset of odorants, which are typically related in structure. Here, we report the odorant response properties of an OR that deviates from this model: SR1, a mouse OR that is abundantly expressed in sensory neurons of the septal organ and also of the main olfactory epithelium. Patch-clamp recordings reveal that olfactory sensory neurons (OSNs) that express SR1 respond to many, structurally unrelated odorants, and over a wide concentration range. Most OSNs expressing a gene-targeted SR1 locus that lacks the SR1 coding sequence do not show this broad responsiveness. Gene transfer in the heterologous expression system Hana3A confirms the broad response profile of SR1. There may be other mouse ORs with such broad response profiles.

Full Text

Duke Authors

Cited Authors

  • Grosmaitre, X; Fuss, SH; Lee, AC; Adipietro, KA; Matsunami, H; Mombaerts, P; Ma, M

Published Date

  • November 18, 2009

Published In

Volume / Issue

  • 29 / 46

Start / End Page

  • 14545 - 14552

PubMed ID

  • 19923288

Pubmed Central ID

  • PMC2818203

Electronic International Standard Serial Number (EISSN)

  • 1529-2401

Digital Object Identifier (DOI)

  • 10.1523/JNEUROSCI.2752-09.2009


  • eng

Conference Location

  • United States