Odor coding by a Mammalian receptor repertoire.

Published online

Journal Article

Deciphering olfactory encoding requires a thorough description of the ligands that activate each odorant receptor (OR). In mammalian systems, however, ligands are known for fewer than 50 of more than 1400 human and mouse ORs, greatly limiting our understanding of olfactory coding. We performed high-throughput screening of 93 odorants against 464 ORs expressed in heterologous cells and identified agonists for 52 mouse and 10 human ORs. We used the resulting interaction profiles to develop a predictive model relating physicochemical odorant properties, OR sequences, and their interactions. Our results provide a basis for translating odorants into receptor neuron responses and for unraveling mammalian odor coding.

Full Text

Duke Authors

Cited Authors

  • Saito, H; Chi, Q; Zhuang, H; Matsunami, H; Mainland, JD

Published Date

  • March 3, 2009

Published In

Volume / Issue

  • 2 / 60

Start / End Page

  • ra9 -

PubMed ID

  • 19261596

Pubmed Central ID

  • 19261596

Electronic International Standard Serial Number (EISSN)

  • 1937-9145

Digital Object Identifier (DOI)

  • 10.1126/scisignal.2000016

Language

  • eng

Conference Location

  • United States