Transient receptor potential (TRP) channels and taste sensation.

Published

Journal Article (Review)

Humans have 5 basic taste sensations: sweet, bitter, sour, salty, and umami (taste of 1-amino acids). Among 33 genes related to transient receptor potential (TRP) channels, 3--including TRP-melastatin 5 (TRPM5), polycystic kidney disease-1-like 3 (PKD1L3), and polycystic kidney disease-2-like 1 (PKD2L1)--are specifically and abundantly expressed in taste receptor cells. TRP-melastatin 5 is co-expressed with taste receptors T1Rs and T2Rs, and functions as a common downstream component in sweet, bitter, and umami taste signal transduction. In contrast, polycystic kidney disease-1-like 3 and polycystic kidney disease-2-like 1 are co-expressed in distinct subsets of taste receptor cells not expressing TRP-melastatin 5. In the heterologous expression system, cells expressing both polycystic kidney disease-1-like 3 and polycystic kidney disease-2-like 1 responded to sour stimuli, showing a unique "off-response" property. Genetic ablation of poly-cystic kidney disease-2-like 1-expressing cells resulted in elimination of gustatory nerve response to sour stimuli, indicating that cells expressing polycystic kidney disease-2-like 1 function as sour taste detectors. These results suggest that polycystic kidney disease-1-like 3/polycystic kidney disease-2-like 1 may play a significant role, possibly as taste receptors, in sour taste sensation.

Full Text

Duke Authors

Cited Authors

  • Ishimaru, Y; Matsunami, H

Published Date

  • March 2009

Published In

Volume / Issue

  • 88 / 3

Start / End Page

  • 212 - 218

PubMed ID

  • 19329452

Pubmed Central ID

  • 19329452

Electronic International Standard Serial Number (EISSN)

  • 1544-0591

Digital Object Identifier (DOI)

  • 10.1177/0022034508330212

Language

  • eng

Conference Location

  • United States