Off-response property of an acid-activated cation channel complex PKD1L3-PKD2L1.

Journal Article (Journal Article)

Ligand-gated ion channels are important in sensory and synaptic transduction. The PKD1L3-PKD2L1 channel complex is a sour taste receptor candidate that is activated by acids. Here, we report that the proton-activated PKD1L3-PKD2L1 ion channels have the unique ability to be activated after the removal of an acid stimulus. We refer to this property as the off-response (previously described as a delayed response). Electrophysiological analyses show that acid-induced responses are observed only after the removal of an acid solution at less than pH 3.0. A small increase in pH is sufficient for PKD1L3-PKD2L1 channel activation, after exposure to an acid at pH 2.5. These results indicate that this channel is a new type of ion channel-designated as an 'off-channel'-which is activated during stimulus application but not gated open until the removal of the stimulus. The off-response property of PKD1L3-PKD2L1 channels might explain the physiological phenomena occurring during sour taste sensation.

Full Text

Duke Authors

Cited Authors

  • Inada, H; Kawabata, F; Ishimaru, Y; Fushiki, T; Matsunami, H; Tominaga, M

Published Date

  • July 2008

Published In

Volume / Issue

  • 9 / 7

Start / End Page

  • 690 - 697

PubMed ID

  • 18535624

Pubmed Central ID

  • PMC2475332

Electronic International Standard Serial Number (EISSN)

  • 1469-3178

Digital Object Identifier (DOI)

  • 10.1038/embor.2008.89


  • eng

Conference Location

  • England