The candidate sour taste receptor, PKD2L1, is expressed by type III taste cells in the mouse.

Published

Journal Article

The transient receptor potential channel, PKD2L1, is reported to be a candidate receptor for sour taste based on molecular biological and functional studies. Here, we investigated the expression pattern of PKD2L1-immunoreactivity (IR) in taste buds of the mouse. PKD2L1-IR is present in a few elongate cells in each taste bud as reported previously. The PKD2L1-expressing cells are different from those expressing PLCbeta2, a marker of Type II cells. Likewise PKD2L1-immunoreactive taste cells do not express ecto-ATPase which marks Type I cells. The PKD2L1-positive cells are immunoreactive for neural cell adhesion molecule, serotonin, PGP-9.5 (ubiquitin carboxy-terminal transferase), and chromogranin A, all of which are present in Type III taste cells. At the ultrastructural level, PKD2L1-immunoreactive cells form synapses onto afferent nerve fibers, another feature of Type III taste cells. These results are consistent with the idea that different taste cells in each taste bud perform distinct functions. We suggest that Type III cells are necessary for transduction and/or transmission of information about "sour", but have little or no role in transmission of taste information of other taste qualities.

Full Text

Duke Authors

Cited Authors

  • Kataoka, S; Yang, R; Ishimaru, Y; Matsunami, H; Sévigny, J; Kinnamon, JC; Finger, TE

Published Date

  • March 2008

Published In

Volume / Issue

  • 33 / 3

Start / End Page

  • 243 - 254

PubMed ID

  • 18156604

Pubmed Central ID

  • 18156604

International Standard Serial Number (ISSN)

  • 0379-864X

Digital Object Identifier (DOI)

  • 10.1093/chemse/bjm083

Language

  • eng

Conference Location

  • England