Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse.

Published

Journal Article

Carbon dioxide (CO2) is an important environmental cue for many organisms but is odorless to humans. It remains unclear whether the mammalian olfactory system can detect CO2 at concentrations around the average atmospheric level (0.038%). We demonstrated the expression of carbonic anhydrase type II (CAII), an enzyme that catabolizes CO2, in a subset of mouse olfactory neurons that express guanylyl cyclase D (GC-D+ neurons) and project axons to necklace glomeruli in the olfactory bulb. Exposure to CO2 activated these GC-D+ neurons, and exposure of a mouse to CO2 activated bulbar neurons associated with necklace glomeruli. Behavioral tests revealed CO2 detection thresholds of approximately 0.066%, and this sensitive CO2 detection required CAII activity. We conclude that mice detect CO2 at near-atmospheric concentrations through the olfactory subsystem of GC-D+ neurons.

Full Text

Duke Authors

Cited Authors

  • Hu, J; Zhong, C; Ding, C; Chi, Q; Walz, A; Mombaerts, P; Matsunami, H; Luo, M

Published Date

  • August 17, 2007

Published In

Volume / Issue

  • 317 / 5840

Start / End Page

  • 953 - 957

PubMed ID

  • 17702944

Pubmed Central ID

  • 17702944

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Digital Object Identifier (DOI)

  • 10.1126/science.1144233

Language

  • eng

Conference Location

  • United States