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Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor.

Publication ,  Journal Article
Ishimaru, Y; Inada, H; Kubota, M; Zhuang, H; Tominaga, M; Matsunami, H
Published in: Proc Natl Acad Sci U S A
August 15, 2006

Animals use their gustatory systems to evaluate the nutritious value, toxicity, sodium content, and acidity of food. Although characterization of molecular identities that receive taste chemicals is essential, molecular receptors underlying sour taste sensation remain unclear. Here, we show that two transient receptor potential (TRP) channel members, PKD1L3 and PKD2L1, are coexpressed in a subset of taste receptor cells in specific taste areas. Cells expressing these molecules are distinct from taste cells having receptors for bitter, sweet, or umami tastants. The PKD2L1 proteins are accumulated at the taste pore region, where taste chemicals are detected. PKD1L3 and PKD2L1 proteins can interact with each other, and coexpression of the PKD1L3 and PKD2L1 is necessary for their functional cell surface expression. Finally, PKD1L3 and PKD2L1 are activated by various acids when coexpressed in heterologous cells but not by other classes of tastants. These results suggest that PKD1L3 and PKD2L1 heteromers may function as sour taste receptors.

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Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

August 15, 2006

Volume

103

Issue

33

Start / End Page

12569 / 12574

Location

United States

Related Subject Headings

  • Taste Buds
  • Taste
  • TRPP Cation Channels
  • TRPM Cation Channels
  • Recombinant Fusion Proteins
  • Receptors, Cell Surface
  • RNA, Messenger
  • Phosphoproteins
  • Patch-Clamp Techniques
  • Models, Molecular
 

Citation

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Ishimaru, Y., Inada, H., Kubota, M., Zhuang, H., Tominaga, M., & Matsunami, H. (2006). Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci U S A, 103(33), 12569–12574. https://doi.org/10.1073/pnas.0602702103
Ishimaru, Yoshiro, Hitoshi Inada, Momoka Kubota, Hanyi Zhuang, Makoto Tominaga, and Hiroaki Matsunami. “Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor.Proc Natl Acad Sci U S A 103, no. 33 (August 15, 2006): 12569–74. https://doi.org/10.1073/pnas.0602702103.
Ishimaru Y, Inada H, Kubota M, Zhuang H, Tominaga M, Matsunami H. Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12569–74.
Ishimaru, Yoshiro, et al. “Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor.Proc Natl Acad Sci U S A, vol. 103, no. 33, Aug. 2006, pp. 12569–74. Pubmed, doi:10.1073/pnas.0602702103.
Ishimaru Y, Inada H, Kubota M, Zhuang H, Tominaga M, Matsunami H. Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12569–12574.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

August 15, 2006

Volume

103

Issue

33

Start / End Page

12569 / 12574

Location

United States

Related Subject Headings

  • Taste Buds
  • Taste
  • TRPP Cation Channels
  • TRPM Cation Channels
  • Recombinant Fusion Proteins
  • Receptors, Cell Surface
  • RNA, Messenger
  • Phosphoproteins
  • Patch-Clamp Techniques
  • Models, Molecular