Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition.

Journal Article (Review;Journal Article)

Gram-positive bacteria pose a serious healthcare threat. The growing antibiotic resistance epidemic creates a dire need for new antibiotic targets. The sortase family of enzymes is a promising target for antimicrobial therapy. This review covers the current knowledge of the mechanism, substrate specificity, and inhibitory studies of the Gram-positive bacterial [corrected] enzyme sortase.

Full Text

Duke Authors

Cited Authors

  • Clancy, KW; Melvin, JA; McCafferty, DG

Published Date

  • January 2010

Published In

Volume / Issue

  • 94 / 4

Start / End Page

  • 385 - 396

PubMed ID

  • 20593474

Pubmed Central ID

  • PMC4648256

Electronic International Standard Serial Number (EISSN)

  • 1097-0282

International Standard Serial Number (ISSN)

  • 0006-3525

Digital Object Identifier (DOI)

  • 10.1002/bip.21472


  • eng