Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition.
Journal Article (Review;Journal Article)
Gram-positive bacteria pose a serious healthcare threat. The growing antibiotic resistance epidemic creates a dire need for new antibiotic targets. The sortase family of enzymes is a promising target for antimicrobial therapy. This review covers the current knowledge of the mechanism, substrate specificity, and inhibitory studies of the Gram-positive bacterial [corrected] enzyme sortase.
Full Text
Duke Authors
Cited Authors
- Clancy, KW; Melvin, JA; McCafferty, DG
Published Date
- January 2010
Published In
Volume / Issue
- 94 / 4
Start / End Page
- 385 - 396
PubMed ID
- 20593474
Pubmed Central ID
- PMC4648256
Electronic International Standard Serial Number (EISSN)
- 1097-0282
International Standard Serial Number (ISSN)
- 0006-3525
Digital Object Identifier (DOI)
- 10.1002/bip.21472
Language
- eng