Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition.

Journal Article (Review;Journal Article)

Gram-positive bacteria pose a serious healthcare threat. The growing antibiotic resistance epidemic creates a dire need for new antibiotic targets. The sortase family of enzymes is a promising target for antimicrobial therapy. This review covers the current knowledge of the mechanism, substrate specificity, and inhibitory studies of the Gram-positive bacterial [corrected] enzyme sortase.

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Duke Authors

McCafferty, Dewey G.

Cited Authors

Clancy, KW; Melvin, JA; McCafferty, DG

Published Date

January 2010

Published In

Biopolymers

Volume / Issue

94 / 4

Start / End Page

385 - 396

PubMed ID

20593474

Pubmed Central ID

PMC4648256

Electronic International Standard Serial Number (EISSN)

1097-0282

International Standard Serial Number (ISSN)

0006-3525

Digital Object Identifier (DOI)

10.1002/bip.21472

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