Facile syntheses of conformationally constrained analogues of lysine and homoglutamic acid
Journal Article (Journal Article)
A facile divergent synthesis of the novel amino acid trans-4-aminoethyl-l- proline and trans-4-carboxymethyl-l-proline from commercially available trans-4-hydroxy-l-proline was developed. These conformationally constrained analogues of l-lysine and l-homoglutamic acid are useful proline templated amino acids (PTAAs) with potential applications in protein engineering and de novo protein design. © 2005 Elsevier Ltd. All rights reserved.
Full Text
Duke Authors
Cited Authors
- Barkallah, S; Schneider, SL; McCafferty, DG
Published Date
- July 25, 2005
Published In
Volume / Issue
- 46 / 30
Start / End Page
- 4985 - 4987
International Standard Serial Number (ISSN)
- 0040-4039
Digital Object Identifier (DOI)
- 10.1016/j.tetlet.2005.05.093
Citation Source
- Scopus