Facile syntheses of conformationally constrained analogues of lysine and homoglutamic acid

Journal Article (Journal Article)

A facile divergent synthesis of the novel amino acid trans-4-aminoethyl-l- proline and trans-4-carboxymethyl-l-proline from commercially available trans-4-hydroxy-l-proline was developed. These conformationally constrained analogues of l-lysine and l-homoglutamic acid are useful proline templated amino acids (PTAAs) with potential applications in protein engineering and de novo protein design. © 2005 Elsevier Ltd. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Barkallah, S; Schneider, SL; McCafferty, DG

Published Date

  • July 25, 2005

Published In

Volume / Issue

  • 46 / 30

Start / End Page

  • 4985 - 4987

International Standard Serial Number (ISSN)

  • 0040-4039

Digital Object Identifier (DOI)

  • 10.1016/j.tetlet.2005.05.093

Citation Source

  • Scopus