Synthesis of P(1)-Citronellyl-P(2)-alpha-D-pyranosyl pyrophosphates as potential substrates for the E. coli undecaprenyl-pyrophosphoryl-N-acetylglucoseaminyl transferase MurG.

Published

Journal Article

P(1)-Citronellyl-P(2)-alpha-D-pyranosyl pyrophosphates containing alpha-D-N-acetylglucoseaminyl, alpha-D-glucosyl, and alpha-D-N-acetylmuramyl carbohydrates were synthesized and used in substrate specificity studies of the Escherichia coli MurG enzyme. Oxalyl chloride activation of citronellyl phosphate for coupling to alpha-D-pyranose-1-phosphates resulted in markedly improved yields over traditional Khorana-Moffatt and diphenyl chlorophosphate activation strategies.

Full Text

Duke Authors

Cited Authors

  • Cudic, P; Behenna, DC; Yu, MK; Kruger, RG; Szewczuk, LM; McCafferty, DG

Published Date

  • December 2001

Published In

Volume / Issue

  • 11 / 24

Start / End Page

  • 3107 - 3110

PubMed ID

  • 11720853

Pubmed Central ID

  • 11720853

Electronic International Standard Serial Number (EISSN)

  • 1464-3405

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/s0960-894x(01)00653-9

Language

  • eng