Synergy and duality in peptide antibiotic mechanisms.

Journal Article (Review;Journal Article)

The molecular mechanisms by which peptide antibiotics disrupt bacterial DNA synthesis, protein biosynthesis, cell wall biosynthesis, and membrane integrity are diverse, yet historically have been understood to follow a theme of one antibiotic, one inhibitory mechanism. In the past year, mechanistic and structural studies have shown a rich diversity in peptide antibiotic mechanism. Novel secondary targeting mechanisms for peptide antibiotics have recently been discovered, and the mechanisms of peptide antibiotics involved in synergistic relationships with antibiotics and proteins have been more clearly defined. In apparent response to selective pressures, antibiotic-producing organisms have elegantly integrated multiple functions and cooperative interactions into peptide antibiotic design for the purpose of improving antimicrobial success.

Full Text

Duke Authors

Cited Authors

  • McCafferty, DG; Cudic, P; Yu, MK; Behenna, DC; Kruger, R

Published Date

  • December 1999

Published In

Volume / Issue

  • 3 / 6

Start / End Page

  • 672 - 680

PubMed ID

  • 10600730

Electronic International Standard Serial Number (EISSN)

  • 1879-0402

International Standard Serial Number (ISSN)

  • 1367-5931

Digital Object Identifier (DOI)

  • 10.1016/s1367-5931(99)00025-3


  • eng