Effects of Nicotine on Emotional Reactivity in PTSD and Non-PTSD Smokers: Results of a Pilot fMRI Study.

Journal Article (Journal Article)

There is evidence that individuals with posttraumatic stress disorder (PTSD) may smoke in part to regulate negative affect. This pilot fMRI study examined the effects of nicotine on emotional information processing in smokers with and without PTSD. Across groups, nicotine increased brain activation in response to fearful/angry faces (compared to neutral faces) in ventral caudate. Patch x Group interactions were observed in brain regions involved in emotional and facial feature processing. These preliminary findings suggest that nicotine differentially modulates negative information processing in PTSD and non-PTSD smokers.

Full Text

Duke Authors

Cited Authors

  • Froeliger, B; Crowell Beckham, J; Feldman Dennis, M; Victoria Kozink, R; Joseph McClernon, F

Published Date

  • 2012

Published In

Volume / Issue

  • 2012 /

Start / End Page

  • 265724 -

PubMed ID

  • 22719754

Pubmed Central ID

  • 22719754

Electronic International Standard Serial Number (EISSN)

  • 1687-6342

Digital Object Identifier (DOI)

  • 10.1155/2012/265724


  • eng

Conference Location

  • United States