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Characterization of a mutation in yeast causing nonrandom chromosome loss during mitosis.

Publication ,  Journal Article
Liras, P; McCusker, J; Mascioli, S; Haber, JE
Published in: Genetics
April 1978

Diploid strains of the yeast Saccharomyces cerevisiae homozygous for a recessive chromosome loss mutation (chl) exhibit a high degree of mitotic instability. Cells become monosomic for chromosome III at a frequency of approximately one percent of all cell divisions. Chromosome loss at this high frequency is also found for chromosome I, and at lesser frequencies for chromosomes VIII and XVI. In contrast, little or no chromosome loss is found for six other linkage groups tested (II, V, VI, VII, XI and XVII). The chl mutation also induces a ten-fold increase in both intergenic and intragenic mitotic recombination on all ten linkage groups tested. The chl mutation does not cause an increase in spontaneous mutations, nor are mutant strains sensitive to UV or irradiation. The effects of chl during meiosis are observed primarily in reduced spore viability. A decrease in chromosome III linkage relationships is also found.

Duke Scholars

Published In

Genetics

ISSN

0016-6731

Publication Date

April 1978

Volume

88

Issue

4 Pt 1

Start / End Page

651 / 671

Location

United States

Related Subject Headings

  • Spores, Fungal
  • Saccharomyces cerevisiae
  • Mutation
  • Mitosis
  • Genes, Mating Type, Fungal
  • Diploidy
  • Developmental Biology
  • Chromosomes, Fungal
  • Chromosome Mapping
  • Chromosome Deletion
 

Citation

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Liras, P., McCusker, J., Mascioli, S., & Haber, J. E. (1978). Characterization of a mutation in yeast causing nonrandom chromosome loss during mitosis. Genetics, 88(4 Pt 1), 651–671.
Liras, P., J. McCusker, S. Mascioli, and J. E. Haber. “Characterization of a mutation in yeast causing nonrandom chromosome loss during mitosis.Genetics 88, no. 4 Pt 1 (April 1978): 651–71.
Liras P, McCusker J, Mascioli S, Haber JE. Characterization of a mutation in yeast causing nonrandom chromosome loss during mitosis. Genetics. 1978 Apr;88(4 Pt 1):651–71.
Liras, P., et al. “Characterization of a mutation in yeast causing nonrandom chromosome loss during mitosis.Genetics, vol. 88, no. 4 Pt 1, Apr. 1978, pp. 651–71.
Liras P, McCusker J, Mascioli S, Haber JE. Characterization of a mutation in yeast causing nonrandom chromosome loss during mitosis. Genetics. 1978 Apr;88(4 Pt 1):651–671.

Published In

Genetics

ISSN

0016-6731

Publication Date

April 1978

Volume

88

Issue

4 Pt 1

Start / End Page

651 / 671

Location

United States

Related Subject Headings

  • Spores, Fungal
  • Saccharomyces cerevisiae
  • Mutation
  • Mitosis
  • Genes, Mating Type, Fungal
  • Diploidy
  • Developmental Biology
  • Chromosomes, Fungal
  • Chromosome Mapping
  • Chromosome Deletion