Unbalanced 5;16 translocation in a boy with papillary thyroid carcinoma.

Journal Article (Journal Article;Review)

This is the first reported case of an unbalanced chromosome rearrangement resulting in trisomy 5q35.5-->qter and monosomy 16p 13.3-->pter, in a boy with mental and growth retardation, minor anomalies, and a history of bilateral papillary thyroid carcinoma. This was the result of a familial balanced translocation. The clinical and cytogenetic manifestations of the case are presented and the possible role of the chromosomal rearrangement in the etiology of the thyroid carcinoma is discussed.

Full Text

Duke Authors

Cited Authors

  • McDonald, M; Maynard, S; Sheldon, S; Innis, J

Published Date

  • February 1, 1994

Published In

Volume / Issue

  • 49 / 3

Start / End Page

  • 288 - 293

PubMed ID

  • 8209888

International Standard Serial Number (ISSN)

  • 0148-7299

Digital Object Identifier (DOI)

  • 10.1002/ajmg.1320490309


  • eng

Conference Location

  • United States