Estrogen-related receptor alpha as a therapeutic target in cancer.
Publication
, Journal Article
Stein, RA; McDonnell, DP
Published in: Endocr Relat Cancer
December 2006
The orphan receptor estrogen-related receptor alpha (ERR alpha) is a member of the nuclear receptor superfamily of ligand-regulated transcription factors. This protein is structurally most related to the canonical estrogen receptor and has been shown to modulate estrogen signaling in some contexts. These observations have heightened interest in ERR alpha as a therapeutic target in both breast and ovarian cancer and in other estrogenopathies. This review details our present understanding of ERR alpha action with a view to highlight specific aspects of its signal-transduction pathway in breast cancer that may be amenable to pharmaceutical manipulation.
Duke Scholars
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Published In
Endocr Relat Cancer
DOI
ISSN
1351-0088
Publication Date
December 2006
Volume
13 Suppl 1
Start / End Page
S25 / S32
Location
England
Related Subject Headings
- Receptors, Estrogen
- Receptor Cross-Talk
- Oncology & Carcinogenesis
- Neoplasms
- Models, Biological
- Humans
- Homeostasis
- Energy Metabolism
- ERRalpha Estrogen-Related Receptor
- Bone and Bones
Citation
APA
Chicago
ICMJE
MLA
NLM
Stein, R. A., & McDonnell, D. P. (2006). Estrogen-related receptor alpha as a therapeutic target in cancer. Endocr Relat Cancer, 13 Suppl 1, S25–S32. https://doi.org/10.1677/erc.1.01292
Stein, R. A., and D. P. McDonnell. “Estrogen-related receptor alpha as a therapeutic target in cancer.” Endocr Relat Cancer 13 Suppl 1 (December 2006): S25–32. https://doi.org/10.1677/erc.1.01292.
Stein RA, McDonnell DP. Estrogen-related receptor alpha as a therapeutic target in cancer. Endocr Relat Cancer. 2006 Dec;13 Suppl 1:S25–32.
Stein, R. A., and D. P. McDonnell. “Estrogen-related receptor alpha as a therapeutic target in cancer.” Endocr Relat Cancer, vol. 13 Suppl 1, Dec. 2006, pp. S25–32. Pubmed, doi:10.1677/erc.1.01292.
Stein RA, McDonnell DP. Estrogen-related receptor alpha as a therapeutic target in cancer. Endocr Relat Cancer. 2006 Dec;13 Suppl 1:S25–S32.
Published In
Endocr Relat Cancer
DOI
ISSN
1351-0088
Publication Date
December 2006
Volume
13 Suppl 1
Start / End Page
S25 / S32
Location
England
Related Subject Headings
- Receptors, Estrogen
- Receptor Cross-Talk
- Oncology & Carcinogenesis
- Neoplasms
- Models, Biological
- Humans
- Homeostasis
- Energy Metabolism
- ERRalpha Estrogen-Related Receptor
- Bone and Bones