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Estrogen-related receptor α as a therapeutic target

Publication ,  Journal Article
Stein, R; Way, JM; McDonnell, DP; Zuercher, WJ
Published in: Drugs of the Future
May 1, 2006

The utility of nuclear receptors (NRs) as targets for drug discovery is well recognized. Growing evidence suggests that ERRα, an orphan NR whose physiological and pathological roles remain under investigation, may have utility in the treatment of various cancer types as well as metabolic and osteopenic disorders. In this article, we review the literature on ERRα as a potential therapeutic target. Within this context we identify several key challenges in progressing small molecules which target ERRα, including the separation of efficacy and liability. Copyright © 2006 Prous Science.

Duke Scholars

Published In

Drugs of the Future

DOI

ISSN

0377-8282

Publication Date

May 1, 2006

Volume

31

Issue

5

Start / End Page

427 / 436

Related Subject Headings

  • Medicinal & Biomolecular Chemistry
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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Stein, R., Way, J. M., McDonnell, D. P., & Zuercher, W. J. (2006). Estrogen-related receptor α as a therapeutic target. Drugs of the Future, 31(5), 427–436. https://doi.org/10.1358/dof.2006.031.05.994706
Stein, R., J. M. Way, D. P. McDonnell, and W. J. Zuercher. “Estrogen-related receptor α as a therapeutic target.” Drugs of the Future 31, no. 5 (May 1, 2006): 427–36. https://doi.org/10.1358/dof.2006.031.05.994706.
Stein R, Way JM, McDonnell DP, Zuercher WJ. Estrogen-related receptor α as a therapeutic target. Drugs of the Future. 2006 May 1;31(5):427–36.
Stein, R., et al. “Estrogen-related receptor α as a therapeutic target.” Drugs of the Future, vol. 31, no. 5, May 2006, pp. 427–36. Scopus, doi:10.1358/dof.2006.031.05.994706.
Stein R, Way JM, McDonnell DP, Zuercher WJ. Estrogen-related receptor α as a therapeutic target. Drugs of the Future. 2006 May 1;31(5):427–436.

Published In

Drugs of the Future

DOI

ISSN

0377-8282

Publication Date

May 1, 2006

Volume

31

Issue

5

Start / End Page

427 / 436

Related Subject Headings

  • Medicinal & Biomolecular Chemistry
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences