Estrogen-related receptor α as a therapeutic target


Journal Article (Review)

The utility of nuclear receptors (NRs) as targets for drug discovery is well recognized. Growing evidence suggests that ERRα, an orphan NR whose physiological and pathological roles remain under investigation, may have utility in the treatment of various cancer types as well as metabolic and osteopenic disorders. In this article, we review the literature on ERRα as a potential therapeutic target. Within this context we identify several key challenges in progressing small molecules which target ERRα, including the separation of efficacy and liability. Copyright © 2006 Prous Science.

Full Text

Duke Authors

Cited Authors

  • Stein, R; Way, JM; McDonnell, DP; Zuercher, WJ

Published Date

  • May 1, 2006

Published In

Volume / Issue

  • 31 / 5

Start / End Page

  • 427 - 436

International Standard Serial Number (ISSN)

  • 0377-8282

Digital Object Identifier (DOI)

  • 10.1358/dof.2006.031.05.994706

Citation Source

  • Scopus