Estrogen-related receptor α as a therapeutic target
Publication
, Journal Article
Stein, R; Way, JM; McDonnell, DP; Zuercher, WJ
Published in: Drugs of the Future
May 1, 2006
The utility of nuclear receptors (NRs) as targets for drug discovery is well recognized. Growing evidence suggests that ERRα, an orphan NR whose physiological and pathological roles remain under investigation, may have utility in the treatment of various cancer types as well as metabolic and osteopenic disorders. In this article, we review the literature on ERRα as a potential therapeutic target. Within this context we identify several key challenges in progressing small molecules which target ERRα, including the separation of efficacy and liability. Copyright © 2006 Prous Science.
Duke Scholars
Published In
Drugs of the Future
DOI
ISSN
0377-8282
Publication Date
May 1, 2006
Volume
31
Issue
5
Start / End Page
427 / 436
Related Subject Headings
- Medicinal & Biomolecular Chemistry
- 3214 Pharmacology and pharmaceutical sciences
- 1115 Pharmacology and Pharmaceutical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Stein, R., Way, J. M., McDonnell, D. P., & Zuercher, W. J. (2006). Estrogen-related receptor α as a therapeutic target. Drugs of the Future, 31(5), 427–436. https://doi.org/10.1358/dof.2006.031.05.994706
Stein, R., J. M. Way, D. P. McDonnell, and W. J. Zuercher. “Estrogen-related receptor α as a therapeutic target.” Drugs of the Future 31, no. 5 (May 1, 2006): 427–36. https://doi.org/10.1358/dof.2006.031.05.994706.
Stein R, Way JM, McDonnell DP, Zuercher WJ. Estrogen-related receptor α as a therapeutic target. Drugs of the Future. 2006 May 1;31(5):427–36.
Stein, R., et al. “Estrogen-related receptor α as a therapeutic target.” Drugs of the Future, vol. 31, no. 5, May 2006, pp. 427–36. Scopus, doi:10.1358/dof.2006.031.05.994706.
Stein R, Way JM, McDonnell DP, Zuercher WJ. Estrogen-related receptor α as a therapeutic target. Drugs of the Future. 2006 May 1;31(5):427–436.
Published In
Drugs of the Future
DOI
ISSN
0377-8282
Publication Date
May 1, 2006
Volume
31
Issue
5
Start / End Page
427 / 436
Related Subject Headings
- Medicinal & Biomolecular Chemistry
- 3214 Pharmacology and pharmaceutical sciences
- 1115 Pharmacology and Pharmaceutical Sciences