Skip to main content

Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: clinical implications.

Publication ,  Journal Article
Kristensen, VN; Sørlie, T; Geisler, J; Langerød, A; Yoshimura, N; Kåresen, R; Harada, N; Lønning, PE; Børresen-Dale, A-L
Published in: Clin Cancer Res
January 15, 2005

Interactions between luminal epithelial cells and their surrounding microenvironment govern the normal development and function of the mammary gland. Estradiol plays a key role in abnormal intracellular signaling, which contributes to the development and progression of breast tumors. The present article summarizes the results from a microarray whole genome gene expression analysis as well as a quantitative analysis of the mRNA expression of members of the estradiol metabolic and signaling pathways in the tumors of postmenopausal breast cancer patients. The analysis of the variation in whole genome gene expression resulted in a tumor classification comprising several distinct groups with distinct expression of the estrogen receptor (ER). The parallel study on the expression of only nine mRNA transcripts of members of the estradiol pathways resulted in two main clusters, representing ER- and ER tumors. The mRNA expression of the estradiol-metabolizing enzymes did not follow the expression of the ER in all cases, leading to the recognition of several further subclasses of tumors. When the tumor classes obtained by whole genome gene expression analysis were compared with those obtained by independent quantitation of the estradiol-metabolizing enzymes, a statistically significant association between both classification groups was observed. These findings point to a possible association between development of a tumor with a particular expression profile and its capacity to synthesize estradiol as measured by the expression of the transcripts for the necessary key enzymes. Further, whole genome expression patterns were studied in 12 patients treated with anastrozole. Using significance analysis of microarrays, we identified 298 genes significantly differently expressed between partial response and progressive disease groups.

Duke Scholars

Published In

Clin Cancer Res

ISSN

1078-0432

Publication Date

January 15, 2005

Volume

11

Issue

2 Pt 2

Start / End Page

878s / 883s

Location

United States

Related Subject Headings

  • Receptors, Estrogen
  • RNA, Messenger
  • Oncology & Carcinogenesis
  • Humans
  • Gene Expression Regulation, Neoplastic
  • Gene Expression Profiling
  • Female
  • Estrogens
  • Estrogen Receptor Modulators
  • Breast Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kristensen, V. N., Sørlie, T., Geisler, J., Langerød, A., Yoshimura, N., Kåresen, R., … Børresen-Dale, A.-L. (2005). Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: clinical implications. Clin Cancer Res, 11(2 Pt 2), 878s-883s.
Kristensen, Vessela N., Therese Sørlie, Jurgen Geisler, Anita Langerød, Noriko Yoshimura, Rolf Kåresen, Nobuhiro Harada, P. E. Lønning, and Anne-Lise Børresen-Dale. “Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: clinical implications.Clin Cancer Res 11, no. 2 Pt 2 (January 15, 2005): 878s-883s.
Kristensen VN, Sørlie T, Geisler J, Langerød A, Yoshimura N, Kåresen R, et al. Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: clinical implications. Clin Cancer Res. 2005 Jan 15;11(2 Pt 2):878s-883s.
Kristensen, Vessela N., et al. “Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: clinical implications.Clin Cancer Res, vol. 11, no. 2 Pt 2, Jan. 2005, pp. 878s-883s.
Kristensen VN, Sørlie T, Geisler J, Langerød A, Yoshimura N, Kåresen R, Harada N, Lønning PE, Børresen-Dale A-L. Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: clinical implications. Clin Cancer Res. 2005 Jan 15;11(2 Pt 2):878s-883s.

Published In

Clin Cancer Res

ISSN

1078-0432

Publication Date

January 15, 2005

Volume

11

Issue

2 Pt 2

Start / End Page

878s / 883s

Location

United States

Related Subject Headings

  • Receptors, Estrogen
  • RNA, Messenger
  • Oncology & Carcinogenesis
  • Humans
  • Gene Expression Regulation, Neoplastic
  • Gene Expression Profiling
  • Female
  • Estrogens
  • Estrogen Receptor Modulators
  • Breast Neoplasms