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Estrogen, estrogen plus progestin therapy, and risk of breast cancer.

Publication ,  Journal Article
Colditz, GA
Published in: Clin Cancer Res
January 15, 2005

Epidemiologic evidence relating use of postmenopausal hormones to risk of breast cancer by nature relies on trends in prescribing practices. Data on the adverse effect of combination estrogen plus progestin used for long durations has only become available over the past decade. Evidence is reviewed relating estrogen alone and estrogen plus progestin to increased risk of breast cancer. Whereas current evidence indicates that longer duration of use increases risk of invasive breast cancer regardless of formulation, the rate of increase in risk is greater for combination estrogen plus progestin therapy. Although data are limited, continuous combined therapy and sequential therapy seem to have comparable impact on breast cancer risk. Combination therapy is more strongly related to lobular breast cancer than is estrogen alone. Unresolved issues remain about dose of estrogen and progestin in relation to risk, and about identification of women for whom short-term use to relieve menopausal symptoms may be safe and effective.

Duke Scholars

Published In

Clin Cancer Res

ISSN

1078-0432

Publication Date

January 15, 2005

Volume

11

Issue

2 Pt 2

Start / End Page

909s / 917s

Location

United States

Related Subject Headings

  • Risk Factors
  • Progestins
  • Postmenopause
  • Oncology & Carcinogenesis
  • Humans
  • Female
  • Estrogens
  • Estrogen Replacement Therapy
  • Drug Therapy, Combination
  • Breast Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Colditz, G. A. (2005). Estrogen, estrogen plus progestin therapy, and risk of breast cancer. Clin Cancer Res, 11(2 Pt 2), 909s-917s.
Colditz, Graham A. “Estrogen, estrogen plus progestin therapy, and risk of breast cancer.Clin Cancer Res 11, no. 2 Pt 2 (January 15, 2005): 909s-917s.
Colditz GA. Estrogen, estrogen plus progestin therapy, and risk of breast cancer. Clin Cancer Res. 2005 Jan 15;11(2 Pt 2):909s-917s.
Colditz, Graham A. “Estrogen, estrogen plus progestin therapy, and risk of breast cancer.Clin Cancer Res, vol. 11, no. 2 Pt 2, Jan. 2005, pp. 909s-917s.
Colditz GA. Estrogen, estrogen plus progestin therapy, and risk of breast cancer. Clin Cancer Res. 2005 Jan 15;11(2 Pt 2):909s-917s.

Published In

Clin Cancer Res

ISSN

1078-0432

Publication Date

January 15, 2005

Volume

11

Issue

2 Pt 2

Start / End Page

909s / 917s

Location

United States

Related Subject Headings

  • Risk Factors
  • Progestins
  • Postmenopause
  • Oncology & Carcinogenesis
  • Humans
  • Female
  • Estrogens
  • Estrogen Replacement Therapy
  • Drug Therapy, Combination
  • Breast Neoplasms