Hormone therapy: physiological complexity belies therapeutic simplicity.

Published

Journal Article (Review)

The results of the Women's Health Initiative, a study anticipated to provide definitive answers about health benefits and risks of postmenopausal hormone therapy, have generated debate and confusion among clinicians, researchers, and the lay public. The ovarian hormones estrogen and progesterone, which decline at menopause, normally elicit complex tissue-specific responses throughout the body. Major advances are providing a detailed molecular definition of how that differential action is achieved. Here we review estrogen and progestin actions, discuss how effectively knowledge of steroid hormone endocrinology has been incorporated into clinical studies, and consider the impact on modern hormone therapy protocols and pharmaceutical development.

Full Text

Duke Authors

Cited Authors

  • Turgeon, JL; McDonnell, DP; Martin, KA; Wise, PM

Published Date

  • May 2004

Published In

Volume / Issue

  • 304 / 5675

Start / End Page

  • 1269 - 1273

PubMed ID

  • 15166356

Pubmed Central ID

  • 15166356

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1096725

Language

  • eng