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Hormone therapy: physiological complexity belies therapeutic simplicity.

Publication ,  Journal Article
Turgeon, JL; McDonnell, DP; Martin, KA; Wise, PM
Published in: Science
May 28, 2004

The results of the Women's Health Initiative, a study anticipated to provide definitive answers about health benefits and risks of postmenopausal hormone therapy, have generated debate and confusion among clinicians, researchers, and the lay public. The ovarian hormones estrogen and progesterone, which decline at menopause, normally elicit complex tissue-specific responses throughout the body. Major advances are providing a detailed molecular definition of how that differential action is achieved. Here we review estrogen and progestin actions, discuss how effectively knowledge of steroid hormone endocrinology has been incorporated into clinical studies, and consider the impact on modern hormone therapy protocols and pharmaceutical development.

Duke Scholars

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Published In

Science

DOI

EISSN

1095-9203

Publication Date

May 28, 2004

Volume

304

Issue

5675

Start / End Page

1269 / 1273

Location

United States

Related Subject Headings

  • Stroke
  • Signal Transduction
  • Receptors, Progesterone
  • Receptors, Estrogen
  • Randomized Controlled Trials as Topic
  • Progesterone
  • Neuroprotective Agents
  • Middle Aged
  • Medroxyprogesterone Acetate
  • Lipid Metabolism
 

Citation

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Turgeon, J. L., McDonnell, D. P., Martin, K. A., & Wise, P. M. (2004). Hormone therapy: physiological complexity belies therapeutic simplicity. Science, 304(5675), 1269–1273. https://doi.org/10.1126/science.1096725
Turgeon, Judith L., Donald P. McDonnell, Kathryn A. Martin, and Phyllis M. Wise. “Hormone therapy: physiological complexity belies therapeutic simplicity.Science 304, no. 5675 (May 28, 2004): 1269–73. https://doi.org/10.1126/science.1096725.
Turgeon JL, McDonnell DP, Martin KA, Wise PM. Hormone therapy: physiological complexity belies therapeutic simplicity. Science. 2004 May 28;304(5675):1269–73.
Turgeon, Judith L., et al. “Hormone therapy: physiological complexity belies therapeutic simplicity.Science, vol. 304, no. 5675, May 2004, pp. 1269–73. Pubmed, doi:10.1126/science.1096725.
Turgeon JL, McDonnell DP, Martin KA, Wise PM. Hormone therapy: physiological complexity belies therapeutic simplicity. Science. 2004 May 28;304(5675):1269–1273.
Journal cover image

Published In

Science

DOI

EISSN

1095-9203

Publication Date

May 28, 2004

Volume

304

Issue

5675

Start / End Page

1269 / 1273

Location

United States

Related Subject Headings

  • Stroke
  • Signal Transduction
  • Receptors, Progesterone
  • Receptors, Estrogen
  • Randomized Controlled Trials as Topic
  • Progesterone
  • Neuroprotective Agents
  • Middle Aged
  • Medroxyprogesterone Acetate
  • Lipid Metabolism