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Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor.

Publication ,  Journal Article
Clemm, DL; Macy, BL; Santiso-Mere, D; McDonnell, DP
Published in: J Steroid Biochem Mol Biol
June 1995

The steroid hormone progesterone is a key modulator of the cellular processes associated with the maintenance and development of female reproductive function. The biological activity of this hormone is mediated by specific nuclear receptors located in target cell nuclei which upon activation are capable of modulating the transcriptional activity of promoters containing progesterone response elements. Abnormalities in the progesterone receptor (PR) signal transduction pathway are implicated in pathological states such as breast cancer, endometriosis, and uterine fibroids. As a result of the medical need to modulate PR transcriptional activity, antiprogestins, compounds which oppose the actions of progesterone and novel progesterone receptor agonists, have been developed. This review outlines our current understanding of the critical cellular components which define the pharmacology of progesterone receptor agonists and antagonists, and how this information will impact the discovery and development of additional therapeutics.

Duke Scholars

Published In

J Steroid Biochem Mol Biol

DOI

ISSN

0960-0760

Publication Date

June 1995

Volume

53

Issue

1-6

Start / End Page

487 / 495

Location

England

Related Subject Headings

  • Transcriptional Activation
  • Transcription, Genetic
  • Structure-Activity Relationship
  • Signal Transduction
  • Repressor Proteins
  • Receptors, Steroid
  • Receptors, Progesterone
  • Promoter Regions, Genetic
  • Progesterone
  • Mifepristone
 

Citation

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Clemm, D. L., Macy, B. L., Santiso-Mere, D., & McDonnell, D. P. (1995). Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor. J Steroid Biochem Mol Biol, 53(1–6), 487–495. https://doi.org/10.1016/0960-0760(95)00095-h
Clemm, D. L., B. L. Macy, D. Santiso-Mere, and D. P. McDonnell. “Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor.J Steroid Biochem Mol Biol 53, no. 1–6 (June 1995): 487–95. https://doi.org/10.1016/0960-0760(95)00095-h.
Clemm DL, Macy BL, Santiso-Mere D, McDonnell DP. Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor. J Steroid Biochem Mol Biol. 1995 Jun;53(1–6):487–95.
Clemm, D. L., et al. “Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor.J Steroid Biochem Mol Biol, vol. 53, no. 1–6, June 1995, pp. 487–95. Pubmed, doi:10.1016/0960-0760(95)00095-h.
Clemm DL, Macy BL, Santiso-Mere D, McDonnell DP. Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor. J Steroid Biochem Mol Biol. 1995 Jun;53(1–6):487–495.
Journal cover image

Published In

J Steroid Biochem Mol Biol

DOI

ISSN

0960-0760

Publication Date

June 1995

Volume

53

Issue

1-6

Start / End Page

487 / 495

Location

England

Related Subject Headings

  • Transcriptional Activation
  • Transcription, Genetic
  • Structure-Activity Relationship
  • Signal Transduction
  • Repressor Proteins
  • Receptors, Steroid
  • Receptors, Progesterone
  • Promoter Regions, Genetic
  • Progesterone
  • Mifepristone