Nuclear hormone receptors as targets for new drug discovery.

Journal Article (Journal Article;Review)

There are two basic types of receptor transducing systems: those which utilize membrane bound receptors and are activated at the cell surface by the appropriate hormone and transmit their signal to the internae of the cell via a second messenger (i.e. cAMP), and those that utilize internal, cytoplasmic or nuclear receptors (intracellular receptors) which upon activation by hormones interact directly with DNA and alter the genetic program of a cell. This review focuses on the mechanism of action of these intracellular receptors and discusses how such an understanding is expected to facilitate the discovery of new therapeutic agents.

Full Text

Duke Authors

Cited Authors

  • McDonnell, DP; Vegeto, E; Gleeson, MA

Published Date

  • November 1993

Published In

Volume / Issue

  • 11 / 11

Start / End Page

  • 1256 - 1261

PubMed ID

  • 7764187

International Standard Serial Number (ISSN)

  • 0733-222X

Digital Object Identifier (DOI)

  • 10.1038/nbt1193-1256


  • eng

Conference Location

  • United States