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Evaluation of HLA polymorphisms in relation to schizophrenia risk and infectious exposure.

Publication ,  Journal Article
Bamne, M; Wood, J; Chowdari, K; Watson, AM; Celik, C; Mansour, H; Klei, L; Gur, RC; Bradford, LD; Calkins, ME; Santos, AB; Edwards, N ...
Published in: Schizophr Bull
November 2012

BACKGROUND: Genome-wide association studies (GWAS) implicate single nucleotide polymorphisms (SNPs) on chromosome 6p21.3-22.1, the human leukocyte antigen (HLA) region, as common risk factors for schizophrenia (SZ). Other studies implicate viral and protozoan exposure. Our study tests chromosome 6p SNPs for effects on SZ risk with and without exposure. METHOD: GWAS-significant SNPs and ancestry-informative marker SNPs were analyzed among African American patients with SZ (n = 604) and controls (n = 404). Exposure to herpes simplex virus, type 1 (HSV-1), cytomegalovirus (CMV), and Toxoplasma gondii (TOX) was assayed using specific antibody assays. RESULTS: Five SNPs were nominally associated with SZ, adjusted for population admixture (P < .05, uncorrected for multiple comparisons). These SNPs were next analyzed in relation to infectious exposure. Multivariate analysis indicated significant association between rs3130297 genotype and HSV-1 exposure; the associated allele was different from the SZ risk allele. CONCLUSIONS: We propose a model for the genesis of SZ incorporating genomic variation in the HLA region and neurotropic viral exposure for testing in additional, independent African American samples.

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Published In

Schizophr Bull

DOI

EISSN

1745-1701

Publication Date

November 2012

Volume

38

Issue

6

Start / End Page

1149 / 1154

Location

United States

Related Subject Headings

  • Toxoplasmosis, Cerebral
  • Schizophrenia
  • Risk Factors
  • Psychiatry
  • Polymorphism, Single Nucleotide
  • Multivariate Analysis
  • Middle Aged
  • Membrane Proteins
  • Male
  • Humans
 

Citation

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Chicago
ICMJE
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Bamne, M., Wood, J., Chowdari, K., Watson, A. M., Celik, C., Mansour, H., … Nimgaonkar, V. L. (2012). Evaluation of HLA polymorphisms in relation to schizophrenia risk and infectious exposure. Schizophr Bull, 38(6), 1149–1154. https://doi.org/10.1093/schbul/sbs087
Bamne, Mikhil, Joel Wood, Kodavali Chowdari, Annie M. Watson, Cemil Celik, Hader Mansour, Lambertus Klei, et al. “Evaluation of HLA polymorphisms in relation to schizophrenia risk and infectious exposure.Schizophr Bull 38, no. 6 (November 2012): 1149–54. https://doi.org/10.1093/schbul/sbs087.
Bamne M, Wood J, Chowdari K, Watson AM, Celik C, Mansour H, et al. Evaluation of HLA polymorphisms in relation to schizophrenia risk and infectious exposure. Schizophr Bull. 2012 Nov;38(6):1149–54.
Bamne, Mikhil, et al. “Evaluation of HLA polymorphisms in relation to schizophrenia risk and infectious exposure.Schizophr Bull, vol. 38, no. 6, Nov. 2012, pp. 1149–54. Pubmed, doi:10.1093/schbul/sbs087.
Bamne M, Wood J, Chowdari K, Watson AM, Celik C, Mansour H, Klei L, Gur RC, Bradford LD, Calkins ME, Santos AB, Edwards N, Kwentus J, McEvoy JP, Allen TB, Savage RM, Nasrallah HA, Gur RE, Perry RT, Go RCP, Devlin B, Yolken R, Nimgaonkar VL. Evaluation of HLA polymorphisms in relation to schizophrenia risk and infectious exposure. Schizophr Bull. 2012 Nov;38(6):1149–1154.
Journal cover image

Published In

Schizophr Bull

DOI

EISSN

1745-1701

Publication Date

November 2012

Volume

38

Issue

6

Start / End Page

1149 / 1154

Location

United States

Related Subject Headings

  • Toxoplasmosis, Cerebral
  • Schizophrenia
  • Risk Factors
  • Psychiatry
  • Polymorphism, Single Nucleotide
  • Multivariate Analysis
  • Middle Aged
  • Membrane Proteins
  • Male
  • Humans