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Early response to antipsychotic therapy as a clinical marker of subsequent response in the treatment of patients with first-episode psychosis.

Publication ,  Journal Article
Stauffer, VL; Case, M; Kinon, BJ; Conley, R; Ascher-Svanum, H; Kollack-Walker, S; Kane, J; McEvoy, J; Lieberman, J
Published in: Psychiatry Res
May 15, 2011

Early response to antipsychotic medication has been shown to accurately predict later response to continued use of the same treatment in patients with chronic schizophrenia. This study examines whether this predictive pattern exists for patients with first-episode psychosis. We used a data-driven threshold for early response of ≥ 26.2% improvement from baseline on the Positive and Negative Syndrome Scale (PANSS(0-6)) Total score to determine whether response at Week 2 of treatment may predict response at Week 12 in a randomized, double-blind trial of olanzapine versus haloperidol for treatment of patients with first-episode psychosis (N=225). Later response was defined as a ≥ 40% and ≥ 50% improvement in PANSS Total(0-6) score and as remission. At Week 2, 43% (97/225) of patients were identified as early responders. At a threshold for later response of ≥ 50% improvement in PANSS(0-6) Total score, early non-response most strongly predicted later non-response, demonstrating high specificity (74%) and high negative predictive value (80%). As had been seen in the treatment of patients with chronic schizophrenia, early non-response was a robust predictor of subsequent non-response in the treatment of patients with first-episode psychosis.

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Published In

Psychiatry Res

DOI

ISSN

0165-1781

Publication Date

May 15, 2011

Volume

187

Issue

1-2

Start / End Page

42 / 48

Location

Ireland

Related Subject Headings

  • Young Adult
  • Weight Gain
  • Treatment Outcome
  • Time Factors
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Predictive Value of Tests
  • Olanzapine
  • Mental Disorders
  • Male
 

Citation

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Stauffer, V. L., Case, M., Kinon, B. J., Conley, R., Ascher-Svanum, H., Kollack-Walker, S., … Lieberman, J. (2011). Early response to antipsychotic therapy as a clinical marker of subsequent response in the treatment of patients with first-episode psychosis. Psychiatry Res, 187(1–2), 42–48. https://doi.org/10.1016/j.psychres.2010.11.017
Stauffer, Virginia L., Michael Case, Bruce J. Kinon, Robert Conley, Haya Ascher-Svanum, Sara Kollack-Walker, John Kane, Joseph McEvoy, and Jeffrey Lieberman. “Early response to antipsychotic therapy as a clinical marker of subsequent response in the treatment of patients with first-episode psychosis.Psychiatry Res 187, no. 1–2 (May 15, 2011): 42–48. https://doi.org/10.1016/j.psychres.2010.11.017.
Stauffer VL, Case M, Kinon BJ, Conley R, Ascher-Svanum H, Kollack-Walker S, et al. Early response to antipsychotic therapy as a clinical marker of subsequent response in the treatment of patients with first-episode psychosis. Psychiatry Res. 2011 May 15;187(1–2):42–8.
Stauffer, Virginia L., et al. “Early response to antipsychotic therapy as a clinical marker of subsequent response in the treatment of patients with first-episode psychosis.Psychiatry Res, vol. 187, no. 1–2, May 2011, pp. 42–48. Pubmed, doi:10.1016/j.psychres.2010.11.017.
Stauffer VL, Case M, Kinon BJ, Conley R, Ascher-Svanum H, Kollack-Walker S, Kane J, McEvoy J, Lieberman J. Early response to antipsychotic therapy as a clinical marker of subsequent response in the treatment of patients with first-episode psychosis. Psychiatry Res. 2011 May 15;187(1–2):42–48.
Journal cover image

Published In

Psychiatry Res

DOI

ISSN

0165-1781

Publication Date

May 15, 2011

Volume

187

Issue

1-2

Start / End Page

42 / 48

Location

Ireland

Related Subject Headings

  • Young Adult
  • Weight Gain
  • Treatment Outcome
  • Time Factors
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Predictive Value of Tests
  • Olanzapine
  • Mental Disorders
  • Male