A candidate gene study of Tardive dyskinesia in the CATIE schizophrenia trial.

Published

Journal Article

Tardive dyskinesia (TD) is a movement disorder characterized by involuntary oro-facial, limb, and truncal movements. As a genetic basis for inter-individual variation is assumed, there have been a sizeable number of candidate gene studies. All subjects met diagnostic criteria for schizophrenia and were randomized to receive antipsychotic medications as participants in the Clinical Antipsychotic Trials of Intervention Effectiveness project (CATIE). TD was assessed via the Abnormal Involuntary Movement Scale at regular intervals. Probable TD was defined as meeting Schooler-Kane criteria at any scheduled CATIE visit (207/710 subjects, 29.2%). A total of 128 candidate genes were studied in 710 subjects-2,580 SNPs in 118 candidate genes selected from the literature (e.g., dopamine, serotonin, glutamate, and GABA pathways) and composite genotypes for 10 drug-metabolizing enzymes. No single marker or haplotype association reached statistical significance after adjustment for multiple comparisons. Thus, we found no support for either novel or prior associations from the literature.

Full Text

Duke Authors

Cited Authors

  • Tsai, H-T; Caroff, SN; Miller, DD; McEvoy, J; Lieberman, JA; North, KE; Stroup, TS; Sullivan, PF

Published Date

  • January 5, 2010

Published In

Volume / Issue

  • 153B / 1

Start / End Page

  • 336 - 340

PubMed ID

  • 19475583

Pubmed Central ID

  • 19475583

Electronic International Standard Serial Number (EISSN)

  • 1552-485X

Digital Object Identifier (DOI)

  • 10.1002/ajmg.b.30981

Language

  • eng

Conference Location

  • United States