Skip to main content
Journal cover image

A candidate gene study of Tardive dyskinesia in the CATIE schizophrenia trial.

Publication ,  Journal Article
Tsai, H-T; Caroff, SN; Miller, DD; McEvoy, J; Lieberman, JA; North, KE; Stroup, TS; Sullivan, PF
Published in: Am J Med Genet B Neuropsychiatr Genet
January 5, 2010

Tardive dyskinesia (TD) is a movement disorder characterized by involuntary oro-facial, limb, and truncal movements. As a genetic basis for inter-individual variation is assumed, there have been a sizeable number of candidate gene studies. All subjects met diagnostic criteria for schizophrenia and were randomized to receive antipsychotic medications as participants in the Clinical Antipsychotic Trials of Intervention Effectiveness project (CATIE). TD was assessed via the Abnormal Involuntary Movement Scale at regular intervals. Probable TD was defined as meeting Schooler-Kane criteria at any scheduled CATIE visit (207/710 subjects, 29.2%). A total of 128 candidate genes were studied in 710 subjects-2,580 SNPs in 118 candidate genes selected from the literature (e.g., dopamine, serotonin, glutamate, and GABA pathways) and composite genotypes for 10 drug-metabolizing enzymes. No single marker or haplotype association reached statistical significance after adjustment for multiple comparisons. Thus, we found no support for either novel or prior associations from the literature.

Duke Scholars

Published In

Am J Med Genet B Neuropsychiatr Genet

DOI

EISSN

1552-485X

Publication Date

January 5, 2010

Volume

153B

Issue

1

Start / End Page

336 / 340

Location

United States

Related Subject Headings

  • Schizophrenia
  • Humans
  • Dyskinesia, Drug-Induced
  • Antipsychotic Agents
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 3105 Genetics
  • 1109 Neurosciences
  • 1103 Clinical Sciences
  • 0604 Genetics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tsai, H.-T., Caroff, S. N., Miller, D. D., McEvoy, J., Lieberman, J. A., North, K. E., … Sullivan, P. F. (2010). A candidate gene study of Tardive dyskinesia in the CATIE schizophrenia trial. Am J Med Genet B Neuropsychiatr Genet, 153B(1), 336–340. https://doi.org/10.1002/ajmg.b.30981
Tsai, Huei-Ting, Stanley N. Caroff, Del D. Miller, Joseph McEvoy, Jeffrey A. Lieberman, Kari E. North, T Scott Stroup, and Patrick F. Sullivan. “A candidate gene study of Tardive dyskinesia in the CATIE schizophrenia trial.Am J Med Genet B Neuropsychiatr Genet 153B, no. 1 (January 5, 2010): 336–40. https://doi.org/10.1002/ajmg.b.30981.
Tsai H-T, Caroff SN, Miller DD, McEvoy J, Lieberman JA, North KE, et al. A candidate gene study of Tardive dyskinesia in the CATIE schizophrenia trial. Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5;153B(1):336–40.
Tsai, Huei-Ting, et al. “A candidate gene study of Tardive dyskinesia in the CATIE schizophrenia trial.Am J Med Genet B Neuropsychiatr Genet, vol. 153B, no. 1, Jan. 2010, pp. 336–40. Pubmed, doi:10.1002/ajmg.b.30981.
Tsai H-T, Caroff SN, Miller DD, McEvoy J, Lieberman JA, North KE, Stroup TS, Sullivan PF. A candidate gene study of Tardive dyskinesia in the CATIE schizophrenia trial. Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5;153B(1):336–340.
Journal cover image

Published In

Am J Med Genet B Neuropsychiatr Genet

DOI

EISSN

1552-485X

Publication Date

January 5, 2010

Volume

153B

Issue

1

Start / End Page

336 / 340

Location

United States

Related Subject Headings

  • Schizophrenia
  • Humans
  • Dyskinesia, Drug-Induced
  • Antipsychotic Agents
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 3105 Genetics
  • 1109 Neurosciences
  • 1103 Clinical Sciences
  • 0604 Genetics