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Project among African-Americans to explore risks for schizophrenia (PAARTNERS): recruitment and assessment methods.

Publication ,  Journal Article
Aliyu, MH; Calkins, ME; Swanson, CL; Lyons, PD; Savage, RM; May, R; Wiener, H; McLeod-Bryant, S; Nimgaonkar, VL; Ragland, JD; Gur, RE; Gur, RC ...
Published in: Schizophr Res
October 2006

The Project among African-Americans to Explore Risks for Schizophrenia (PAARTNERS) is a multi-site, NIMH-funded study that seeks to identify genetic polymorphisms that confer susceptibility to schizophrenia among African-Americans by linkage mapping and targeted association analyses. Because deficits in certain dimensions of cognitive ability are thought to underlie liability to schizophrenia, the project also examines cognitive abilities in individuals affected by schizophrenia and their extended family members. This article describes PAARTNERS study design, ascertainment methods and preliminary sample characteristics. We aim to recruit a sample of 1260 African-American families, all of whom have at least one proband with schizophrenia or schizoaffective disorder. The data collection protocol includes a structured Diagnostic Interview for Genetic Studies, Family Interview for Genetic Studies, focused neurocognitive assessment, medical records review, and the collection of blood or buccal cells for genetic analyses. We have currently completed study procedures for 106 affected sib-pair, 457 case-parent trio and 23 multiplex families. A total of 289 probands have completed the best estimate final diagnosis process and 1153 probands and family members have been administered the computerized neuropsychological battery. This project lays the foundation for future analysis of cognitive and behavioral endophenotypes. This novel integration of diagnostic, neurocognitive and genetic data will also generate valuable information for future phenotypic and genetic studies of schizophrenia.

Duke Scholars

Published In

Schizophr Res

DOI

ISSN

0920-9964

Publication Date

October 2006

Volume

87

Issue

1-3

Start / End Page

32 / 44

Location

Netherlands

Related Subject Headings

  • Severity of Illness Index
  • Schizophrenia
  • Risk Factors
  • Psychiatry
  • Polymorphism, Genetic
  • Patient Selection
  • Neuropsychological Tests
  • Middle Aged
  • Mass Screening
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Aliyu, M. H., Calkins, M. E., Swanson, C. L., Lyons, P. D., Savage, R. M., May, R., … PAARTNERS Study Group, . (2006). Project among African-Americans to explore risks for schizophrenia (PAARTNERS): recruitment and assessment methods. Schizophr Res, 87(1–3), 32–44. https://doi.org/10.1016/j.schres.2006.06.027
Aliyu, Muktar H., Monica E. Calkins, Charlie L. Swanson, Paul D. Lyons, Robert M. Savage, Roberta May, Howard Wiener, et al. “Project among African-Americans to explore risks for schizophrenia (PAARTNERS): recruitment and assessment methods.Schizophr Res 87, no. 1–3 (October 2006): 32–44. https://doi.org/10.1016/j.schres.2006.06.027.
Aliyu MH, Calkins ME, Swanson CL, Lyons PD, Savage RM, May R, et al. Project among African-Americans to explore risks for schizophrenia (PAARTNERS): recruitment and assessment methods. Schizophr Res. 2006 Oct;87(1–3):32–44.
Aliyu, Muktar H., et al. “Project among African-Americans to explore risks for schizophrenia (PAARTNERS): recruitment and assessment methods.Schizophr Res, vol. 87, no. 1–3, Oct. 2006, pp. 32–44. Pubmed, doi:10.1016/j.schres.2006.06.027.
Aliyu MH, Calkins ME, Swanson CL, Lyons PD, Savage RM, May R, Wiener H, McLeod-Bryant S, Nimgaonkar VL, Ragland JD, Gur RE, Gur RC, Bradford LD, Edwards N, Kwentus J, McEvoy JP, Santos AB, McCleod-Bryant S, Tennison C, Go RCP, Allen TB, PAARTNERS Study Group. Project among African-Americans to explore risks for schizophrenia (PAARTNERS): recruitment and assessment methods. Schizophr Res. 2006 Oct;87(1–3):32–44.
Journal cover image

Published In

Schizophr Res

DOI

ISSN

0920-9964

Publication Date

October 2006

Volume

87

Issue

1-3

Start / End Page

32 / 44

Location

Netherlands

Related Subject Headings

  • Severity of Illness Index
  • Schizophrenia
  • Risk Factors
  • Psychiatry
  • Polymorphism, Genetic
  • Patient Selection
  • Neuropsychological Tests
  • Middle Aged
  • Mass Screening
  • Male