Suggestive association between the C825T polymorphism of the G-protein beta3 subunit gene (GNB3) and clinical improvement with antipsychotics in schizophrenia.

Journal Article (Journal Article;Multicenter Study)

G-proteins are composed of alpha, beta and gamma subunits. Once activated, these subunits play a major role in the conversion of external receptor activation into intracellular signals. The functional C825T polymorphism of the beta3 subunit gene (GNB3) has recently been shown to modulate antidepressant response, with the T-allele conferring an increased signaling and being associated with favorable antidepressant response. We hypothesized that this polymorphism may be associated with response to antipsychotics in a population of 145 chronic schizophrenic patients deriving from two study-samples and being mainly treated with clozapine for up to 6 months. Overall, the C/C genotype was significantly associated with relative clinical improvement as measured by Brief Psychiatric Rating Scale (BPRS) change scores after 6 and 12 weeks (p<0.01 and p=0.03, respectively), with estimated effect sizes ranging from 4.8 to 7%. Our results further suggest that this effect is only attributable to Caucasians when compared to African-Americans. Moreover, our findings point to the role of intracellular mechanisms in antipsychotic response.

Full Text

Duke Authors

Cited Authors

  • Müller, DJ; De Luca, V; Sicard, T; King, N; Hwang, R; Volavka, J; Czobor, P; Sheitman, BB; Lindenmayer, J-P; Citrome, L; McEvoy, JP; Lieberman, JA; Meltzer, HY; Kennedy, JL

Published Date

  • October 2005

Published In

Volume / Issue

  • 15 / 5

Start / End Page

  • 525 - 531

PubMed ID

  • 16139171

International Standard Serial Number (ISSN)

  • 0924-977X

Digital Object Identifier (DOI)

  • 10.1016/j.euroneuro.2005.02.001


  • eng

Conference Location

  • Netherlands