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Aggression and psychopathology in treatment-resistant inpatients with schizophrenia and schizoaffective disorder.

Publication ,  Journal Article
Nolan, KA; Volavka, J; Czobor, P; Sheitman, B; Lindenmayer, J-P; Citrome, LL; McEvoy, J; Lieberman, JA
Published in: J Psychiatr Res
January 2005

Positive psychotic symptoms, such as threat/"control-override" delusions or command hallucinations, have been related to aggression in patients with schizophrenia. However, retrospective data collection has hampered evaluation of the direct influence of psychopathology on aggressive behavior. In this study, we monitored aggressive behavior and psychopathology prospectively and in close temporal proximity in 157 treatment-resistant inpatients diagnosed with chronic schizophrenia or schizoaffective disorder participating in a 14-week double-blind clinical trial. Aggressive behavior was rated with the overt aggression scale (OAS). Psychopathology was assessed using the positive and negative syndrome scale (PANSS). At baseline, subjects who would be aggressive during the study had higher scores on only two PANSS items: hostility and poor impulse control. During the study PANSS positive subscale scores were significantly higher in aggressive subjects. Total PANSS scores were higher within 3 days of an aggressive incident, as were positive and general psychopathology subscale scores. However, in a smaller subsample for whom PANSS ratings were available within 3 days before aggressive incidents, only scores on the PANSS positive subscale were significantly higher. These findings in chronic, treatment resistant inpatients support the view that positive symptoms may lead to aggression.

Duke Scholars

Published In

J Psychiatr Res

DOI

ISSN

0022-3956

Publication Date

January 2005

Volume

39

Issue

1

Start / End Page

109 / 115

Location

England

Related Subject Headings

  • Severity of Illness Index
  • Schizophrenic Psychology
  • Schizophrenia
  • Psychotic Disorders
  • Psychiatry
  • Prospective Studies
  • Mental Disorders
  • Humans
  • Drug Resistance
  • Double-Blind Method
 

Citation

APA
Chicago
ICMJE
MLA
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Nolan, K. A., Volavka, J., Czobor, P., Sheitman, B., Lindenmayer, J.-P., Citrome, L. L., … Lieberman, J. A. (2005). Aggression and psychopathology in treatment-resistant inpatients with schizophrenia and schizoaffective disorder. J Psychiatr Res, 39(1), 109–115. https://doi.org/10.1016/j.jpsychires.2004.04.010
Nolan, Karen A., Jan Volavka, Pal Czobor, Brian Sheitman, Jean-Pierre Lindenmayer, Leslie L. Citrome, Joseph McEvoy, and Jeffrey A. Lieberman. “Aggression and psychopathology in treatment-resistant inpatients with schizophrenia and schizoaffective disorder.J Psychiatr Res 39, no. 1 (January 2005): 109–15. https://doi.org/10.1016/j.jpsychires.2004.04.010.
Nolan KA, Volavka J, Czobor P, Sheitman B, Lindenmayer J-P, Citrome LL, et al. Aggression and psychopathology in treatment-resistant inpatients with schizophrenia and schizoaffective disorder. J Psychiatr Res. 2005 Jan;39(1):109–15.
Nolan, Karen A., et al. “Aggression and psychopathology in treatment-resistant inpatients with schizophrenia and schizoaffective disorder.J Psychiatr Res, vol. 39, no. 1, Jan. 2005, pp. 109–15. Pubmed, doi:10.1016/j.jpsychires.2004.04.010.
Nolan KA, Volavka J, Czobor P, Sheitman B, Lindenmayer J-P, Citrome LL, McEvoy J, Lieberman JA. Aggression and psychopathology in treatment-resistant inpatients with schizophrenia and schizoaffective disorder. J Psychiatr Res. 2005 Jan;39(1):109–115.
Journal cover image

Published In

J Psychiatr Res

DOI

ISSN

0022-3956

Publication Date

January 2005

Volume

39

Issue

1

Start / End Page

109 / 115

Location

England

Related Subject Headings

  • Severity of Illness Index
  • Schizophrenic Psychology
  • Schizophrenia
  • Psychotic Disorders
  • Psychiatry
  • Prospective Studies
  • Mental Disorders
  • Humans
  • Drug Resistance
  • Double-Blind Method