Antipsychotic-induced weight gain and therapeutic response: a differential association.

Journal Article (Journal Article;Multicenter Study)

This study investigated the association between antipsychotic-induced weight gain and therapeutic response to haloperidol and three commonly used atypical neuroleptic medications in schizophrenia and schizoaffective disorder. The subjects were 151 patients enrolled in a double-blind experiment with a duration of 14 weeks comparing the therapeutic efficacy of haloperidol (n = 36), clozapine (n = 38), olanzapine (n = 38), and risperidone (n = 39). Absolute and relative (%) gain in body weight and body mass index (BMI) was determined for the entire duration of the double-blind treatment period; therapeutic response was assessed by the total score and the individual subscales of the Positive and Negative Symptom Scale. Compared with the pretreatment baseline, results indicated that for olanzapine and clozapine, therapeutic response was closely related to an absolute and relative gain in weight and to a gain in BMI. No association between weight gain and therapeutic response was found for risperidone and haloperidol. These findings suggest that patients who are likely to have the maximal benefits of olanzapine or clozapine treatment for symptom alleviation are at the highest risk of a clinically significant increase in weight gain.

Full Text

Duke Authors

Cited Authors

  • Czobor, P; Volavka, J; Sheitman, B; Lindenmayer, J-P; Citrome, L; McEvoy, J; Cooper, TB; Chakos, M; Lieberman, JA

Published Date

  • June 2002

Published In

Volume / Issue

  • 22 / 3

Start / End Page

  • 244 - 251

PubMed ID

  • 12006893

International Standard Serial Number (ISSN)

  • 0271-0749

Digital Object Identifier (DOI)

  • 10.1097/00004714-200206000-00003


  • eng

Conference Location

  • United States