Neurotrophin-3 levels in the cerebrospinal fluid of patients with schizophrenia or medical illness

Journal Article

Neurotrophin-3 (NT-3) may have a potential role in the pathogenesis of schizophrenia, given evidence of abnormal neurodevelopment in schizophrenia, as well as a potential association of an NT-3 gene polymorphism with schizophrenia. Cerebrospinal fluid NT-3 protein was assayed using an enzyme- linked immunosorbent assay in five patients with schizophrenia and 49 patients with medical illness. None of the patients with schizophrenia had detectable levels of NT-3 (above 4.7 pg/ml). Eleven samples from 10 different patients with medical or neurological illness had detectable levels of NT-3, associated with surgery for hydrocephalus or central nervous system infection.

Full Text

Duke Authors

Cited Authors

  • Gilmore, JH; Jarskog, LF; Lindgren, JC; McEvoy, JP; Xiao, H

Published Date

  • 1997

Published In

Volume / Issue

  • 73 / 1-2

Start / End Page

  • 109 - 113

International Standard Serial Number (ISSN)

  • 0165-1781

Digital Object Identifier (DOI)

  • 10.1016/S0165-1781(97)00116-9