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Optimal dose of neuroleptic in acute schizophrenia. A controlled study of the neuroleptic threshold and higher haloperidol dose.

Publication ,  Journal Article
McEvoy, JP; Hogarty, GE; Steingard, S
Published in: Arch Gen Psychiatry
August 1991

After individual determination of neuroleptic threshold (NT) doses of haloperidol, 106 patients with schizophrenia or schizoaffective disorder (Research Diagnostic Criteria) were treated openly at such doses (mean, 3.7 +/- 2.3 mg/d) for 2 weeks. Ten responding patients were discharged and unavailable for follow-up or refused subsequent randomization, and one non-responding patient refused randomization. The remaining 95 responding or nonresponding patients were then randomly assigned, double-blind, to a dosage of haloperidol two to 10 times higher (mean, 11.6 +/- 4.7 mg/d) or to a continuing NT dosage (mean, 3.4 +/- 2.3 mg/d) for another 2 weeks. Of the 58 patients exposed only to NT dosages of haloperidol, 72% clinically recovered within the 5-week trial. Higher dosages given to 47 patients did not lead to greater improvement in measures of psychosis, but did produce slightly greater declines in measures of hostility. Higher dosages did regularly lead to significant increases in distressing extrapyramidal side effects.

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Published In

Arch Gen Psychiatry

DOI

ISSN

0003-990X

Publication Date

August 1991

Volume

48

Issue

8

Start / End Page

739 / 745

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Schizophrenic Psychology
  • Schizophrenia
  • Psychotic Disorders
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Middle Aged
  • Male
  • Humans
  • Haloperidol
 

Citation

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McEvoy, J. P., Hogarty, G. E., & Steingard, S. (1991). Optimal dose of neuroleptic in acute schizophrenia. A controlled study of the neuroleptic threshold and higher haloperidol dose. Arch Gen Psychiatry, 48(8), 739–745. https://doi.org/10.1001/archpsyc.1991.01810320063009
McEvoy, J. P., G. E. Hogarty, and S. Steingard. “Optimal dose of neuroleptic in acute schizophrenia. A controlled study of the neuroleptic threshold and higher haloperidol dose.Arch Gen Psychiatry 48, no. 8 (August 1991): 739–45. https://doi.org/10.1001/archpsyc.1991.01810320063009.
McEvoy, J. P., et al. “Optimal dose of neuroleptic in acute schizophrenia. A controlled study of the neuroleptic threshold and higher haloperidol dose.Arch Gen Psychiatry, vol. 48, no. 8, Aug. 1991, pp. 739–45. Pubmed, doi:10.1001/archpsyc.1991.01810320063009.

Published In

Arch Gen Psychiatry

DOI

ISSN

0003-990X

Publication Date

August 1991

Volume

48

Issue

8

Start / End Page

739 / 745

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Schizophrenic Psychology
  • Schizophrenia
  • Psychotic Disorders
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Middle Aged
  • Male
  • Humans
  • Haloperidol