Roles of bilayer material properties in function and distribution of membrane proteins.

Journal Article (Journal Article;Review)

Structural, compositional, and material (elastic) properties of lipid bilayers exert strong influences on the interactions of water-soluble proteins and peptides with membranes, the distribution of transmembrane proteins in the plane of the membrane, and the function of specific membrane channels. Theoretical and experimental studies show that the binding of either cytoplasmic proteins or extracellular peptides to membranes is regulated by the presence of charged lipids and that the sorting of transmembrane proteins into or out of membrane microdomains (rafts) depends on several factors, including bilayer material properties governed by the presence of cholesterol. Recent studies have also shown that bilayer material properties modify the permeability of membrane pores, formed either by protein channels or by cell-lytic peptides.

Full Text

Duke Authors

Cited Authors

  • McIntosh, TJ; Simon, SA

Published Date

  • 2006

Published In

Volume / Issue

  • 35 /

Start / End Page

  • 177 - 198

PubMed ID

  • 16689633

International Standard Serial Number (ISSN)

  • 1056-8700

Digital Object Identifier (DOI)

  • 10.1146/annurev.biophys.35.040405.102022


  • eng

Conference Location

  • United States