Temporal lobe epilepsy and the BDNF receptor, TrkB

Journal Article (Journal Article)

Brain derived neurotrophic factor (BDNF) regulates diverse neuronal functions and plasticity, and its expression is increased by seizures. Here we review the evidence that actions of BDNF at TrkB receptors contribute to temporal lobe epilepsy. In addition, regulation of BDNF by steroid hormones might explain syndromes such as catamenial epilepsy. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at). © 2010 International League Against Epilepsy.

Full Text

Duke Authors

Cited Authors

  • McNamara, JO; Scharfman, HE

Published Date

  • December 1, 2010

Published In

Volume / Issue

  • 51 / SUPPL. 5

Start / End Page

  • 46 -

Electronic International Standard Serial Number (EISSN)

  • 1528-1167

International Standard Serial Number (ISSN)

  • 0013-9580

Digital Object Identifier (DOI)

  • 10.1111/j.1528-1167.2010.02832.x

Citation Source

  • Scopus