Fas(t) balls and Lou Gehrig disease. A clue to selective vulnerability of motor neurons?

Journal Article (Journal Article;Review)

The molecular basis of the selective death of motor neurons in amyotrophic lateral sclerosis (ALS) has been an enigma since its description by Charcot in 1869. In this issue of Neuron, demonstrate a motor neuron-specific death pathway which involves Fas and NO. Remarkably, motor neurons from mice carrying ALS-linked mutant forms of superoxide dismutase 1 (SOD1) exhibit an increased sensitivity to death triggered by Fas but not other insults. These data suggest new insights into the mechanisms of, and potential therapeutic strategies for, death of motor neurons in ALS.

Full Text

Duke Authors

Cited Authors

  • Xiong, Z-Q; McNamara, JO

Published Date

  • September 12, 2002

Published In

Volume / Issue

  • 35 / 6

Start / End Page

  • 1011 - 1013

PubMed ID

  • 12354390

International Standard Serial Number (ISSN)

  • 0896-6273

Digital Object Identifier (DOI)

  • 10.1016/s0896-6273(02)00910-8


  • eng

Conference Location

  • United States