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Selective inhibition of kindling development by intraventricular administration of TrkB receptor body.

Publication ,  Journal Article
Binder, DK; Routbort, MJ; Ryan, TE; Yancopoulos, GD; McNamara, JO
Published in: J Neurosci
February 15, 1999

Recent work has shown that neurotrophin gene expression is increased after seizures evoked in the kindling model of epilepsy, but whether neurotrophins regulate kindling development is as yet unclear. In this study, we attempted to block selectively the activation of distinct neurotrophin receptors throughout kindling development in the rat via chronic intracerebroventricular administration of trk receptor bodies. The efficacy and selectivity of the trk receptor bodies were established by inhibition of neurotrophin-induced trk receptor phosphorylation in pheochromocytoma (PC12) cells and primary cultures of cortical neurons. The intracerebroventricular infusion of trkB receptor body (trkB-Fc) inhibited development of kindling in comparison with that seen with saline or human IgG controls, trkA-Fc, or trkC-Fc. These results imply that activation of trkB receptors contributes to the development of kindling, a form of activity-dependent behavioral plasticity in the adult mammalian brain.

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Published In

J Neurosci

DOI

ISSN

0270-6474

Publication Date

February 15, 1999

Volume

19

Issue

4

Start / End Page

1424 / 1436

Location

United States

Related Subject Headings

  • Receptors, Nerve Growth Factor
  • Receptor, Ciliary Neurotrophic Factor
  • Receptor Protein-Tyrosine Kinases
  • Rats, Sprague-Dawley
  • Rats
  • Neuroprotective Agents
  • Neurology & Neurosurgery
  • Male
  • Kindling, Neurologic
  • Injections, Intraventricular
 

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Binder, D. K., Routbort, M. J., Ryan, T. E., Yancopoulos, G. D., & McNamara, J. O. (1999). Selective inhibition of kindling development by intraventricular administration of TrkB receptor body. J Neurosci, 19(4), 1424–1436. https://doi.org/10.1523/JNEUROSCI.19-04-01424.1999
Binder, D. K., M. J. Routbort, T. E. Ryan, G. D. Yancopoulos, and J. O. McNamara. “Selective inhibition of kindling development by intraventricular administration of TrkB receptor body.J Neurosci 19, no. 4 (February 15, 1999): 1424–36. https://doi.org/10.1523/JNEUROSCI.19-04-01424.1999.
Binder DK, Routbort MJ, Ryan TE, Yancopoulos GD, McNamara JO. Selective inhibition of kindling development by intraventricular administration of TrkB receptor body. J Neurosci. 1999 Feb 15;19(4):1424–36.
Binder, D. K., et al. “Selective inhibition of kindling development by intraventricular administration of TrkB receptor body.J Neurosci, vol. 19, no. 4, Feb. 1999, pp. 1424–36. Pubmed, doi:10.1523/JNEUROSCI.19-04-01424.1999.
Binder DK, Routbort MJ, Ryan TE, Yancopoulos GD, McNamara JO. Selective inhibition of kindling development by intraventricular administration of TrkB receptor body. J Neurosci. 1999 Feb 15;19(4):1424–1436.

Published In

J Neurosci

DOI

ISSN

0270-6474

Publication Date

February 15, 1999

Volume

19

Issue

4

Start / End Page

1424 / 1436

Location

United States

Related Subject Headings

  • Receptors, Nerve Growth Factor
  • Receptor, Ciliary Neurotrophic Factor
  • Receptor Protein-Tyrosine Kinases
  • Rats, Sprague-Dawley
  • Rats
  • Neuroprotective Agents
  • Neurology & Neurosurgery
  • Male
  • Kindling, Neurologic
  • Injections, Intraventricular