Experimental partial epileptogenesis.

Journal Article (Review)

Identification of the responsible mutant genes and of the functional consequences of the mutations in experimental preparations have begun to shed light on mechanisms underlying a rare form of partial epilepsy in humans, autosomal dominant nocturnal frontal lobe epilepsy. Likewise, study of the mechanisms of nongenetic models of a common form of human epilepsy, complex partial epilepsy of temporal lobe origin, has established the hippocampal dentate granule cells as a functional barrier to invasion of epileptiform activity into hippocampus in normal brain; this barrier is defective in an epileptic brain. Potential mechanisms by which the 'barrier function' might become flawed, such as mossy fiber sprouting, are discussed.

Full Text

Duke Authors

Cited Authors

  • Bausch, SB; McNamara, JO

Published Date

  • April 1999

Published In

Volume / Issue

  • 12 / 2

Start / End Page

  • 203 - 209

PubMed ID

  • 10226754

Pubmed Central ID

  • 10226754

International Standard Serial Number (ISSN)

  • 1350-7540

Digital Object Identifier (DOI)

  • 10.1097/00019052-199904000-00012


  • eng

Conference Location

  • England