Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy.
Publication
, Journal Article
Wilson, MH; Puranam, RS; Ottman, R; Gilliam, C; Limbird, LE; George, AL; McNamara, JO
Published in: Neurology
December 1998
An autosomal dominant form of human temporal lobe epilepsy (TLE) has been mapped to a region of chromosome 10q that contains the intronless alpha(2A)-adrenergic receptor (alpha(2A)AR) gene. Because mutation of the alpha(2A)AR gene in the mouse fosters epileptogenesis, we developed methods for analysis of the alpha(2A)AR coding region applicable to any pathophysiologic state in which the alpha(2A)AR could be implicated in the disease mechanism. This study rules out mutations in the alpha(2A)AR coding region as causal for this form of autosomal dominant TLE.
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Published In
Neurology
DOI
ISSN
0028-3878
Publication Date
December 1998
Volume
51
Issue
6
Start / End Page
1730 / 1731
Location
United States
Related Subject Headings
- Receptors, Adrenergic, alpha-2
- Neurology & Neurosurgery
- Mutation
- Mice
- Humans
- Genes, Dominant
- Epilepsy, Temporal Lobe
- DNA Primers
- Chromosomes, Human, Pair 10
- Brain Chemistry
Citation
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MLA
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Wilson, M. H., Puranam, R. S., Ottman, R., Gilliam, C., Limbird, L. E., George, A. L., & McNamara, J. O. (1998). Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy. Neurology, 51(6), 1730–1731. https://doi.org/10.1212/wnl.51.6.1730
Wilson, M. H., R. S. Puranam, R. Ottman, C. Gilliam, L. E. Limbird, A. L. George, and J. O. McNamara. “Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy.” Neurology 51, no. 6 (December 1998): 1730–31. https://doi.org/10.1212/wnl.51.6.1730.
Wilson MH, Puranam RS, Ottman R, Gilliam C, Limbird LE, George AL, et al. Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy. Neurology. 1998 Dec;51(6):1730–1.
Wilson, M. H., et al. “Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy.” Neurology, vol. 51, no. 6, Dec. 1998, pp. 1730–31. Pubmed, doi:10.1212/wnl.51.6.1730.
Wilson MH, Puranam RS, Ottman R, Gilliam C, Limbird LE, George AL, McNamara JO. Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy. Neurology. 1998 Dec;51(6):1730–1731.
Published In
Neurology
DOI
ISSN
0028-3878
Publication Date
December 1998
Volume
51
Issue
6
Start / End Page
1730 / 1731
Location
United States
Related Subject Headings
- Receptors, Adrenergic, alpha-2
- Neurology & Neurosurgery
- Mutation
- Mice
- Humans
- Genes, Dominant
- Epilepsy, Temporal Lobe
- DNA Primers
- Chromosomes, Human, Pair 10
- Brain Chemistry