Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy.

Journal Article (Journal Article)

An autosomal dominant form of human temporal lobe epilepsy (TLE) has been mapped to a region of chromosome 10q that contains the intronless alpha(2A)-adrenergic receptor (alpha(2A)AR) gene. Because mutation of the alpha(2A)AR gene in the mouse fosters epileptogenesis, we developed methods for analysis of the alpha(2A)AR coding region applicable to any pathophysiologic state in which the alpha(2A)AR could be implicated in the disease mechanism. This study rules out mutations in the alpha(2A)AR coding region as causal for this form of autosomal dominant TLE.

Full Text

Duke Authors

Cited Authors

  • Wilson, MH; Puranam, RS; Ottman, R; Gilliam, C; Limbird, LE; George, AL; McNamara, JO

Published Date

  • December 1998

Published In

Volume / Issue

  • 51 / 6

Start / End Page

  • 1730 - 1731

PubMed ID

  • 9855534

International Standard Serial Number (ISSN)

  • 0028-3878

Digital Object Identifier (DOI)

  • 10.1212/wnl.51.6.1730


  • eng

Conference Location

  • United States