Analyses of the molecular basis of kindling development.


Journal Article (Review)

Kindling has become the most widely studied animal model of limbic epilepsy. Understanding the molecular basis of kindling development may provide novel therapeutic approaches to prevention of limbic epileptogenesis. I briefly describe the kindling model and outline the basis for my thinking that kindling represents a synaptic reorganization triggered by pathologic activity in the mature nervous system. The pathologic activity is postulated to evoke a cascade of gene expression driven, at least in part, by glutamate receptor activation. Evidence in support of this hypothesis is presented, as are future challenges that permit critical tests of these ideas.

Full Text

Duke Authors

Cited Authors

  • McNamara, JO

Published Date

  • June 1995

Published In

Volume / Issue

  • 49 / 3

Start / End Page

  • S175 - S178

PubMed ID

  • 8612137

Pubmed Central ID

  • 8612137

International Standard Serial Number (ISSN)

  • 1323-1316

Digital Object Identifier (DOI)

  • 10.1111/j.1440-1819.1995.tb02167.x


  • eng

Conference Location

  • Australia